| Additive pressor effects of caffeine and stress in male medical students at risk for hypertension. | |
| | |
MedLine Citation:
|
PMID: 10826397 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effects of caffeine on blood pressure (BP) and cortisol secretion were examined during elevated work stress in medical students at high versus low risk for hypertension. Among 31 male medical students who were regular consumers of caffeine, 20 were considered at low risk for hypertension (negative parental history and all screening BP < 125/78 mm Hg) and 11 at high risk based on epidemiologic criteria (positive parental history and average screening BPs between 125/78 and 139/89 mm Hg). Cortisol levels and ambulatory BP were measured with and without caffeine during two lectures (low work stress) and two exams (high work stress) in a randomized, double-blind, crossover trial. Caffeine consumption and exam stress increased cortisol secretion in both groups (P < .05). BP increased with caffeine or exam stress in both groups, low versus high risk, respectively (Caffeine: + 5/4 vs + 3/3 mm Hg; Stress: + 4/1 vs + 7/3 mm Hg; P < .05). The combination of stress and caffeine caused additive increases in BP (Low Risk + 9/5 mm Hg, High Risk + 10/6 mm Hg) such that 46% of high-risk participants had average systolic BP > or = 140 mm Hg. This combined effect of stress and caffeine on BP suggests that it may be beneficial for individuals at high risk for hypertension to refrain from the use of caffeinated beverages, particularly at times when work demands and attendant stressors are high. For the same reasons, recent intake of caffeine should be controlled in patients undergoing BP measurement for the diagnosis of hypertension. |
| | |
Authors:
|
J D Shepard; M al'Absi; T L Whitsett; R B Passey; W R Lovallo |
Related Documents
:
|
3307307 - Dietary calcium intake and blood pressure in normotensive subjects. 11847547 - Beneficial effect of a long-term antihypertensive therapy on blood pressure response to... 18593517 - Efficacy and tolerability of combination therapy with valsartan/hydrochlorothiazide in ... 19534037 - The risks and benefits of initial irbesartan/hydrochlorothiazide combination therapy in... 3740507 - Dose-dependent effects of bupivacaine on rat muscle arterioles. 9179317 - Enhanced increase of plasma sodium pump inhibitory activity to saline expansion in vago... |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: American journal of hypertension Volume: 13 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2000 May |
Date Detail:
|
Created Date: 2000-09-12 Completed Date: 2000-09-12 Revised Date: 2009-02-24 |
Medline Journal Info:
|
Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 475-81 Citation Subset: IM |
Affiliation:
|
Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Blood Pressure / physiology* Blood Pressure Monitoring, Ambulatory Caffeine / adverse effects* Central Nervous System Stimulants / adverse effects* Cross-Over Studies Double-Blind Method Humans Hydrocortisone / blood Hypertension / blood, etiology* Male Questionnaires Reference Values Risk Factors Saliva / metabolism Stress, Psychological / complications* Students, Medical |
| Grant Support | |
ID/Acronym/Agency:
|
HL32050/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Central Nervous System Stimulants; 50-23-7/Hydrocortisone; 58-08-2/Caffeine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The addition of doxazosin to the therapeutic regimen of hypertensive patients inadequately controlle...
Next Document: Association between alcohol intake and development of hypertension in Japanese normotensive men: 12-...