Document Detail

Additive nature of distension and surfactant perturbation on alveolocapillary permeability.
MedLine Citation:
PMID:  9032514     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to determine whether the effects of alveolar distention and surfactant dysfunction on alveolocapillary barrier function are different and additive. Pulmonary clearance of aerosolized technetium-99m-labelled human serum albumin (99mTc-HSA) was used to characterize barrier function after perturbing the surfactant system with the detergent dioctyl sodium sulphosuccinate either singly or in combination with large tidal volume ventilation (LTVV). Clearance was measured for 3 h (Experimental ventilation) in four groups (n = 6 each) of rabbits: 1) Controls; 2) Detergent; 3) LTVV; and 4) Detergent + LTVV. Restoration of clearance (Recovery) was studied for 3 h under conventional ventilation. The half-life of clearance (t 1/2) decreased during LTVV (305 min) compared to 1,055 min in Controls. Detergent induced a biexponential clearance with slow (t 1/2S) and fast (t 1/2F) half-lives of 670 and 15.4 min, respectively. The fast fraction (fF) was 0.20. Clearance in the Detergent + LTVV group was also biexponential. The t 1/2F and fF were similar to the Detergent group. The t 1/2S was similar to the LTVV group. The fF in this group increased to 0.36 during Recovery (p < 0.01 versus Detergent group and p < 0.05 versus Experimental ventilation). The diverse kinetics of clearance during large tidal volume ventilation and surfactant dysfunction suggest the presence of different mechanisms affecting the barrier. The mechanisms have additive characteristics, which superimpose to produce lung injury.
J John; V Taskar; E Evander; P Wollmer; B Jonson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European respiratory journal     Volume:  10     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-04-29     Completed Date:  1997-04-29     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  192-9     Citation Subset:  IM    
Dept of Clinical Physiology, University Hospital of Lund, Sweden.
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MeSH Terms
Analysis of Variance
Blood-Air Barrier / drug effects,  physiology*
Carbon Dioxide / blood
Detergents / pharmacology
Dioctyl Sulfosuccinic Acid / pharmacology
Lung / drug effects,  metabolism,  physiopathology
Metabolic Clearance Rate
Oxygen / blood
Positive-Pressure Respiration
Pulmonary Alveoli / drug effects,  metabolism,  physiopathology*
Pulmonary Surfactants / antagonists & inhibitors*,  physiology
Respiration, Artificial*
Respiratory Mechanics / physiology
Technetium Tc 99m Aggregated Albumin / administration & dosage,  diagnostic use,  pharmacokinetics
Tidal Volume
Reg. No./Substance:
0/Aerosols; 0/Detergents; 0/Pulmonary Surfactants; 0/Technetium Tc 99m Aggregated Albumin; 10041-19-7/Dioctyl Sulfosuccinic Acid; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

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