| Additive nature of distension and surfactant perturbation on alveolocapillary permeability. | |
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MedLine Citation:
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PMID: 9032514 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to determine whether the effects of alveolar distention and surfactant dysfunction on alveolocapillary barrier function are different and additive. Pulmonary clearance of aerosolized technetium-99m-labelled human serum albumin (99mTc-HSA) was used to characterize barrier function after perturbing the surfactant system with the detergent dioctyl sodium sulphosuccinate either singly or in combination with large tidal volume ventilation (LTVV). Clearance was measured for 3 h (Experimental ventilation) in four groups (n = 6 each) of rabbits: 1) Controls; 2) Detergent; 3) LTVV; and 4) Detergent + LTVV. Restoration of clearance (Recovery) was studied for 3 h under conventional ventilation. The half-life of clearance (t 1/2) decreased during LTVV (305 min) compared to 1,055 min in Controls. Detergent induced a biexponential clearance with slow (t 1/2S) and fast (t 1/2F) half-lives of 670 and 15.4 min, respectively. The fast fraction (fF) was 0.20. Clearance in the Detergent + LTVV group was also biexponential. The t 1/2F and fF were similar to the Detergent group. The t 1/2S was similar to the LTVV group. The fF in this group increased to 0.36 during Recovery (p < 0.01 versus Detergent group and p < 0.05 versus Experimental ventilation). The diverse kinetics of clearance during large tidal volume ventilation and surfactant dysfunction suggest the presence of different mechanisms affecting the barrier. The mechanisms have additive characteristics, which superimpose to produce lung injury. |
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Authors:
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J John; V Taskar; E Evander; P Wollmer; B Jonson |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: 10 ISSN: 0903-1936 ISO Abbreviation: Eur. Respir. J. Publication Date: 1997 Jan |
Date Detail:
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Created Date: 1997-04-29 Completed Date: 1997-04-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: DENMARK |
Other Details:
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Languages: eng Pagination: 192-9 Citation Subset: IM |
Affiliation:
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Dept of Clinical Physiology, University Hospital of Lund, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aerosols Analysis of Variance Animals Blood-Air Barrier / drug effects, physiology* Carbon Dioxide / blood Detergents / pharmacology Dioctyl Sulfosuccinic Acid / pharmacology Half-Life Lung / drug effects, metabolism, physiopathology Metabolic Clearance Rate Oxygen / blood Positive-Pressure Respiration Pulmonary Alveoli / drug effects, metabolism, physiopathology* Pulmonary Surfactants / antagonists & inhibitors*, physiology Rabbits Respiration, Artificial* Respiratory Mechanics / physiology Technetium Tc 99m Aggregated Albumin / administration & dosage, diagnostic use, pharmacokinetics Tidal Volume |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; 0/Detergents; 0/Pulmonary Surfactants; 0/Technetium Tc 99m Aggregated Albumin; 10041-19-7/Dioctyl Sulfosuccinic Acid; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen |
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