Document Detail


Additive-multiplicative rates model for recurrent events.
MedLine Citation:
PMID:  20229314     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recurrent events are frequently encountered in biomedical studies. Evaluating the covariates effects on the marginal recurrent event rate is of practical interest. There are mainly two types of rate models for the recurrent event data: the multiplicative rates model and the additive rates model. We consider a more flexible additive-multiplicative rates model for analysis of recurrent event data, wherein some covariate effects are additive while others are multiplicative. We formulate estimating equations for estimating the regression parameters. The estimators for these regression parameters are shown to be consistent and asymptotically normally distributed under appropriate regularity conditions. Moreover, the estimator of the baseline mean function is proposed and its large sample properties are investigated. We also conduct simulation studies to evaluate the finite sample behavior of the proposed estimators. A medical study of patients with cystic fibrosis suffered from recurrent pulmonary exacerbations is provided for illustration of the proposed method.
Authors:
Yanyan Liu; Yuanshan Wu; Jianwen Cai; Haibo Zhou
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-03-14
Journal Detail:
Title:  Lifetime data analysis     Volume:  16     ISSN:  1572-9249     ISO Abbreviation:  Lifetime Data Anal     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-10     Completed Date:  2010-09-14     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  9516348     Medline TA:  Lifetime Data Anal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  353-73     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Clinical Trials as Topic*
Computer Simulation
Cystic Fibrosis / drug therapy,  pathology
Deoxyribonucleases / therapeutic use
Humans
Models, Statistical*
Recurrence*
Grant Support
ID/Acronym/Agency:
R01 CA 79949/CA/NCI NIH HHS; R01 CA079949/CA/NCI NIH HHS; R01 HL 57444/HL/NHLBI NIH HHS; R01 HL057444/HL/NHLBI NIH HHS; R01 HL057444-13/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
EC 3.1.-/Deoxyribonucleases
Comments/Corrections

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