| Additive improvement induced by bezafibrate in patients with primary biliary cirrhosis showing refractory response to ursodeoxycholic acid. | |
| | |
MedLine Citation:
|
PMID: 21443659 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background: Ursodeoxycholic acid (UDCA) has been widely used in the treatment of patients with primary biliary cirrhosis (PBC). However, some patients are refractory to UDCA. The aim of this study is to clarify the additive improvement induced by bezafibrate in patients refractory to UDCA. Methods: This study was a prospective analysis of 37 consecutive PBC patients. All patients were treated first for 6 months with UDCA, and then with bezafibrate, if their ALP levels did not decrease more than 40% or within normal range after 6 months' treatment with UDCA. Clinical parameters were monitored for subsequent 24 months. Result: Twenty two patients (59%) achieved improvement of ALP levels after the treatment with UDCA. Those patients (Group A) had significantly lower levels of ALP at diagnosis than those with abnormal ALP levels after 6 months' treatment with UDCA (Group B; p = 0.020). They continued UDCA monotherapy, and maintained normal ALP levels at subsequent follow-ups. However, immunoglobulin M (IgM) levels remained abnormal in 8 patients, whose IgM levels at the time of diagnosis were significantly higher than those whose IgM were normalized after 6 months' treatment with UDCA (p = 0.026). Those in Group B were treated additionally with bezafibrate, and 12 patients (80%) achieved normal ALP and IgM levels within 12 months of commencement of therapy. Conclusion: Higher ALP level at diagnosis is one of the predictors for UDCA failure. Combination treatment of bezafibrate in addition to UDCA may be an effective treatment for PBC patients refractory to UDCA. |
| | |
Authors:
|
Yasuto Takeuchi; Fusao Ikeda; Shin-Ichi Fujioka; Toshiyuki Takaki; Toshiya Osawa; Tetsuya Yasunaka; Yasuhiro Miyake; Akinobu Takaki; Yoshiaki Iwasaki; Haruhiko Kobashi; Kazuhide Yamamoto; Tatsuya Itoshima |
Related Documents
:
|
12525449 - Induction of spermatogenesis in azoospermic men after varicocele repair. 21148439 - Very early mobilization after stroke fast-tracks return to walking: further results fro... 21141019 - Efficacy of latanoprost in management of chronic angle closure glaucoma. 12832359 - Lower sperm aneuploidy frequency is associated with high pregnancy rates in icsi progra... 21490989 - The effect of pulsed electromagnetic fields on the acceleration of tooth movement. 21145269 - Quality of life in patients with small abdominal aortic aneurysm: the effect of early e... 15612959 - Role of arterial blood gas abnormalities in oedema formation in copd. 18343679 - Temporary neurological dysfunction after surgery of the thoracic aorta: a predictor of ... 19815159 - Asymmetry of the lips of orthognathic surgery patients. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-28 |
Journal Detail:
|
Title: Journal of gastroenterology and hepatology Volume: - ISSN: 1440-1746 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-29 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8607909 Medline TA: J Gastroenterol Hepatol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd. |
Affiliation:
|
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Department of Internal Medicine, Okayama Saiseikai General Hospital, Okayama, Department of Molecular Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: TRANSIENT ELASTOGRAPHIC EVALUATION IN ADULT SUBJECTS WITHOUT OVERT LIVER DISEASE: INFLUENCE OF ALANI...
Next Document: Molecular mechanisms of hepatocarcinogenesis in chronic hepatitis C virus infection.