| Additive host genetic factors influence fecal egg excretion rates during Schistosoma mansoni infection in a rural area in Brazil. | |
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MedLine Citation:
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PMID: 12452486 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study quantifies the influence of shared household and kinship on egg counts during Schistosoma mansoni infection in a sample from rural Brazil. Detailed genealogic information allowed assignment of 597 individuals to 6 multihousehold pedigrees residing in 145 households. A variance component method was used to partition egg counts into shared household, additive genetic, and individual-specific environmental effects. Host additive genetic effects consistently accounted for a large proportion of the variation in egg counts: 43% in an unadjusted model and 40% in model adjusted for covariates. In a model that examined the confounding of shared household with kinship, additive genetic effects still accounted for 27% of the variation in egg counts and shared household only 12%. The consistently important role for host additive genetic factors on the variation in egg counts points to new ways of modeling and understanding the mechanisms that contribute to trait variation during infection with S. mansoni. |
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Authors:
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J Bethony; J T Williams; J Blangero; H Kloos; A Gazzinelli; B Soares-Filho; L Coelho; L Alves-Fraga; S Williams-Blangero; P T Loverde; R Correa-Oliveira |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of tropical medicine and hygiene Volume: 67 ISSN: 0002-9637 ISO Abbreviation: Am. J. Trop. Med. Hyg. Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-11-27 Completed Date: 2002-12-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370507 Medline TA: Am J Trop Med Hyg Country: United States |
Other Details:
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Languages: eng Pagination: 336-43 Citation Subset: AIM; IM |
Affiliation:
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Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, DC, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brazil / epidemiology Feces / parasitology* Genetic Predisposition to Disease* Likelihood Functions Parasite Egg Count* Rural Population* Schistosoma mansoni / isolation & purification* Schistosomiasis / epidemiology, parasitology*, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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1K01 TW00009/TW/FIC NIH HHS; AI45451-01/AI/NIAID NIH HHS; MH59490/MH/NIMH NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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