Document Detail

Additive effect of epinephrine to timolol therapy in primary open angle glaucoma.
MedLine Citation:
PMID:  7065957     Owner:  NLM     Status:  MEDLINE    
Previous studies have suggested that the effect on intraocular pressure resulting from the combined use of timolol and epinephrine might be different when they are administered hours rather than minutes apart. Fourteen patients were randomly assigned to one of two treatment sequences in which 1% epinephrine borate was added either five minutes or three hours after 0.5% timolol maleate. Combined therapy was continued for two weeks, after which epinephrine administration was stopped for a two-week washout period. The patient groups were then crossed over to the other dosage interval. There was an initial enhancement of pressure reduction when epinephrine was added to timolol in both sequences. After crossover, epinephrine was significantly additive to timolol in reducing pressure only when administered three hours after timolol. This additive effect was still present after three months of combined therapy.
M N Cyrlin; J V Thomas; D L Epstein
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  100     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  1982 Mar 
Date Detail:
Created Date:  1982-05-21     Completed Date:  1982-05-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  414-8     Citation Subset:  AIM; IM    
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MeSH Terms
Drug Administration Schedule
Drug Therapy, Combination
Epinephrine / pharmacology,  therapeutic use*
Glaucoma, Open-Angle / drug therapy*
Intraocular Pressure / drug effects*
Middle Aged
Propanolamines / therapeutic use*
Timolol / pharmacology,  therapeutic use*
Grant Support
Reg. No./Substance:
0/Propanolamines; 26839-75-8/Timolol; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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