| Additive concentration effects on enantioselective separations in supercritical fluid chromatography. | |
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MedLine Citation:
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PMID: 12666233 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Polar additive concentration effects in supercritical fluid chromatography were studied on chiral stationary phases having either a macrocyclic glycopeptide or a derivatized polysaccharide as the chiral selector. Two basic additives, isopropylamine and triethylamine, were incorporated into the methanol modifier at various concentrations and the effects on retention, selectivity, and resolution were monitored. Many of the analytes failed to elute from the macrocyclic glycopeptide stationary phase in the absence of an additive and the most noticeable effect of increasing additive concentration was a significant decrease in retention. On the derivatized polysaccharide stationary phase the additives had little effect on retention, but they did foster significant improvements in peak shape and resolution. |
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Authors:
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Karen W Phinney; Lane C Sander |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chirality Volume: 15 ISSN: 0899-0042 ISO Abbreviation: Chirality Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-03-31 Completed Date: 2003-06-13 Revised Date: 2003-11-04 |
Medline Journal Info:
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Nlm Unique ID: 8914261 Medline TA: Chirality Country: United States |
Other Details:
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Languages: eng Pagination: 287-94 Citation Subset: - |
Copyright Information:
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Published 2003 Wiley-Liss, Inc. |
Affiliation:
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Analytical Chemistry Division, Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, Maryland 20899-8392, USA. karen.phinney@nist.gov |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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