Document Detail

Additive antihypertensive and antihypertrophic effects of long-acting Ca blockers in uncontrolled hypertensive patients with angiotensin-receptor blocker based treatment.
MedLine Citation:
PMID:  19809205     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to examine the antihypertensive and antihypertrophic effects of combined treatment with a long-acting calcium antagonist on top of an angiotensin II receptor blocker (ARB) in uncontrolled hypertensive patients. Patients with essential hypertension and a blood pressure > 140/90 mmHg on ARB monotherapy (losartan 50 mg/day or candesartan 8 mg/day) were randomly assigned to a nifedipine controlled release (CR) group (n = 15) or amlodipine group (n = 11). A significant additional antihypertensive effect was noted from 1 month with nifedipine and 2 months with amlodipine. The average daily dose was 25 mg for nifedipine and 5 mg for amlodipine. The cardiothoracic ratio was significantly reduced in both groups after 3 months. Left ventricular wall thickness and left ventricular mass index also decreased. Metabolic parameters, hepatic function, and renal function did not change significantly. Additional treatment with a long-acting calcium antagonist achieved further blood pressure reduction as well as an antihypertrophic effect in the uncontrolled patients with prior ARB monotherapy.
Sunao Kodama; Yukiko Inoue; Kei Miyoshi; Shunichiro Sumi; Keisuke Okamura; Hideaki Tojyo; Chie Ando; Hideya Niimura; Yoshihiro Tsuchiya; Hiroyuki Mihara; Yoshio Yamanouchi; Hidenori Urata
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International heart journal     Volume:  50     ISSN:  1349-2365     ISO Abbreviation:  Int Heart J     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-10-07     Completed Date:  2009-11-10     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  101244240     Medline TA:  Int Heart J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  555-70     Citation Subset:  IM    
Department of Cardiovascular Diseases, Fukuoka University Chikushi Hospital, Fukuoka, Japan.
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MeSH Terms
Amlodipine / administration & dosage*
Benzimidazoles / administration & dosage*
Calcium Channel Blockers / administration & dosage*
Drug Therapy, Combination
Hypertension / drug therapy*
Losartan / administration & dosage*
Middle Aged
Nifedipine / administration & dosage*
Tetrazoles / administration & dosage*
Reg. No./Substance:
0/Benzimidazoles; 0/Calcium Channel Blockers; 0/Tetrazoles; 114798-26-4/Losartan; 21829-25-4/Nifedipine; 88150-42-9/Amlodipine; S8Q36MD2XX/candesartan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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