| Additive antihypertensive and antihypertrophic effects of long-acting Ca blockers in uncontrolled hypertensive patients with angiotensin-receptor blocker based treatment. | |
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MedLine Citation:
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PMID: 19809205 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the present study was to examine the antihypertensive and antihypertrophic effects of combined treatment with a long-acting calcium antagonist on top of an angiotensin II receptor blocker (ARB) in uncontrolled hypertensive patients. Patients with essential hypertension and a blood pressure > 140/90 mmHg on ARB monotherapy (losartan 50 mg/day or candesartan 8 mg/day) were randomly assigned to a nifedipine controlled release (CR) group (n = 15) or amlodipine group (n = 11). A significant additional antihypertensive effect was noted from 1 month with nifedipine and 2 months with amlodipine. The average daily dose was 25 mg for nifedipine and 5 mg for amlodipine. The cardiothoracic ratio was significantly reduced in both groups after 3 months. Left ventricular wall thickness and left ventricular mass index also decreased. Metabolic parameters, hepatic function, and renal function did not change significantly. Additional treatment with a long-acting calcium antagonist achieved further blood pressure reduction as well as an antihypertrophic effect in the uncontrolled patients with prior ARB monotherapy. |
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Authors:
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Sunao Kodama; Yukiko Inoue; Kei Miyoshi; Shunichiro Sumi; Keisuke Okamura; Hideaki Tojyo; Chie Ando; Hideya Niimura; Yoshihiro Tsuchiya; Hiroyuki Mihara; Yoshio Yamanouchi; Hidenori Urata |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: International heart journal Volume: 50 ISSN: 1349-2365 ISO Abbreviation: - Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-10-07 Completed Date: 2009-11-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101244240 Medline TA: Int Heart J Country: Japan |
Other Details:
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Languages: eng Pagination: 555-70 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Diseases, Fukuoka University Chikushi Hospital, Fukuoka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Amlodipine / administration & dosage* Benzimidazoles / administration & dosage* Calcium Channel Blockers / administration & dosage* Drug Therapy, Combination Female Humans Hypertension / drug therapy* Losartan / administration & dosage* Male Middle Aged Nifedipine / administration & dosage* Tetrazoles / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Benzimidazoles; 0/Calcium Channel Blockers; 0/Tetrazoles; 114798-26-4/Losartan; 139481-59-7/candesartan; 21829-25-4/Nifedipine; 88150-42-9/Amlodipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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