| Additive intraocular pressure reduction effect of fixed combination of maleate timolol 0.5%/dorzolamide 2% (Cosopt) on monotherapy with latanoprost (Xalatan) in patients with elevated intraocular pressure: a prospective, 4-week, open-label, randomized, controlled clinical trial. | |
| | |
MedLine Citation:
|
PMID: 19730119 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To evaluate the additive effect of dorzolamide/timolol fixed combination in patients under monotherapy with latanoprost. PATIENTS AND METHODS: In this prospective, 4-week, randomized, open-label controlled clinical trial, patients with open-angle glaucoma or ocular hypertension, which presented at least 15% intraocular pressure (IOP) reduction after a minimum period of 15 days of monotherapy with latanoprost and whose IOP level was considered above the established target-IOP level were randomized to receive fixed combination of timolol/dorzolamide twice daily in one of eyes. The fellow eye was kept under monotherapy and was included in the control group. A modified diurnal tension curve (mDTC) followed by the water drinking test were performed in the baseline and week 4 visits to evaluate IOP profile between groups. RESULTS: Forty-nine per-protocol patients were analyzed. After latanoprost monotherapy run-in period, IOP levels were significantly reduced (P<0.001) in both control and study groups to 15.34+/-2.96 mm Hg and 15.24+/-2.84 mm Hg (30.8% and 32.2% IOP reduction, respectively; P=0.552). At week 4, mean baseline diurnal IOP levels were 15.60+/-3.09 and 14.44+/-3.03 (7.4% difference; P=0.01). Mean baseline IOP modified diurnal tension curve peak after latanoprost run-in period were 17.47+/-3.68 mm Hg and 17.02+/-3.35 mm Hg (control and study eyes, respectively; P=0.530). At week 4 visit, mean water-drinking test peaks were significantly reduced in the study eye group in comparison with the control group: 19.02+/-3.81 mm Hg and 20.39+/-4.19 mm Hg, respectively (6.7% reduction; P=0.039). CONCLUSIONS: In our sample, dorzolamide 2%/timolol 0.5% fixed combination as add-on therapy in patients with open-angle glaucoma or ocular hypertension under monotherapy with latanoprost with IOP already in mid-teens levels may further enhance pressure reduction. |
| | |
Authors:
|
Marcelo Hatanaka; Alexandre Reis; Milena Eimi Sano; Remo Susanna |
Related Documents
:
|
9059269 - Acute iop elevation with scleral suction: effects on retrobulbar haemodynamics. 7387959 - Timolol in operated closed-angle glaucoma. 8755199 - Effect of seasons upon intraocular pressure in healthy population of china. 20019759 - Efficacy and safety of fixed combinations of latanoprost/timolol and dorzolamide/timolo... 11360559 - Effect of third trimester of pregnancy on diurnal variation of ocular pressure. 4063249 - Progression of field loss after trabeculectomy: a five-year follow-up. 8410249 - Catecholamine response to a gradual increase of intracranial pressure. 17996519 - Acute effects of his bundle pacing versus left ventricular and right ventricular pacing... 21962929 - High pressure magnetic resonance imaging with metallic vessels. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of glaucoma Volume: 19 ISSN: 1536-481X ISO Abbreviation: J. Glaucoma Publication Date: 2010 Jun-Jul |
Date Detail:
|
Created Date: 2010-06-14 Completed Date: 2010-09-24 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9300903 Medline TA: J Glaucoma Country: United States |
Other Details:
|
Languages: eng Pagination: 331-5 Citation Subset: IM |
Affiliation:
|
Department of Ophthalmology, School of Medicine, University of Sao Paulo, Brazil. info@centroavancado.net |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Antihypertensive Agents / administration & dosage* Drug Combinations Female Glaucoma, Open-Angle / diagnosis, drug therapy* Humans Intraocular Pressure / drug effects* Male Middle Aged Ocular Hypertension / diagnosis, drug therapy Prospective Studies Prostaglandins F, Synthetic / administration & dosage* Sulfonamides / administration & dosage* Thiophenes / administration & dosage* Time Factors Timolol / administration & dosage* Tonometry, Ocular Treatment Outcome Visual Acuity |
| Chemical | |
Reg. No./Substance:
|
0/Antihypertensive Agents; 0/Drug Combinations; 0/Prostaglandins F, Synthetic; 0/Sulfonamides; 0/Thiophenes; 0/dorzolamide-timolol combination; 130209-82-4/latanoprost; 26839-75-8/Timolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Serum Cytokine Alteration is Associated with Optic Neuropathy in Human Primary Open Angle Glaucoma.
Next Document: Effect of Cataract Extraction on the Glaucoma Progression Index (GPI) in Glaucoma Patients.