| Additional value of hybrid PET/CT fusion imaging vs. conventional CT scan alone in the staging and management of patients with malignant pleural mesothelioma. | |
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MedLine Citation:
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PMID: 16437396 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Despite being a relatively rare disease, the incidence of malignant pleural mesothelioma (MPM) is expected to increase over the next two decades due to the long time interval elapsing between exposure to causative factors, mainly asbestos, and disease onset. Early disease stages have been reported to benefit from radical surgery. In more advanced disease stages, a multimodality treatment, including various combinations of chemotherapy, external radiotherapy and surgery, may provide some favourable results though the prognosis remains poor. In this regard, an accurate pre-treatment staging plays an important role in offering patients a more appropriate therapeutic planning. In some preliminary studies, (18)F-FDG PET has proven to be able to provide useful information for staging purpose, especially for the detection of metastatic spread to lymph nodes and distant sites. MATERIAL AND METHODS: In the present study, we investigated 15 consecutive patients with histologically proven MPM by means of conventional 2-mm thickness whole-body CT scan with and without contrast medium in comparison with wholebody (18)F-FDG PET/CT fusion imaging. RESULTS: (18)F-FDG PET/CT did not provide additional information about the primary tumour (T) compared to CT scan, but identified a higher number of metastatic mediastinal lymph nodes (N) in 6 patients (40% of cases) and unknown metastatic disease to distant sites (M) in 3 patients (20% of cases). On the basis of PET/CT findings, treatment planning was changed in 5 patients (33.3% of cases). CONCLUSIONS: Our data show that (18)F-FDG PET/CT fusion imaging can play a relevant role in the staging and treatment planning of MPM patients. |
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Authors:
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Valentina Ambrosini; Domenico Rubello; Cristina Nanni; Mohsen Farsad; Paolo Castellucci; Roberto Franchi; Mario Fabbri; Lucia Rampin; Giorgio Crepaldi; Adil Al-Nahhas; Stefano Fanti |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Nuclear medicine review. Central & Eastern Europe Volume: 8 ISSN: 1506-9680 ISO Abbreviation: Nucl Med Rev Cent East Eur Publication Date: 2005 |
Date Detail:
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Created Date: 2006-01-26 Completed Date: 2006-02-28 Revised Date: 2011-10-13 |
Medline Journal Info:
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Nlm Unique ID: 100886103 Medline TA: Nucl Med Rev Cent East Eur Country: Poland |
Other Details:
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Languages: eng Pagination: 111-5 Citation Subset: IM |
Affiliation:
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Nuclear Medicine Service - PET Unit, Policlinico S. Orsola-Malpighi, Bologna University, Bologna, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Female Humans Image Enhancement / methods Male Mesothelioma / radiography*, radionuclide imaging* Middle Aged Neoplasm Staging Pleural Neoplasms / radiography*, radionuclide imaging* Positron-Emission Tomography / methods* Prognosis Reproducibility of Results Sensitivity and Specificity Subtraction Technique* Tomography, X-Ray Computed / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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