| Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice. | |
| | |
MedLine Citation:
|
PMID: 19833123 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The Additional sex combs (Asx) gene of Drosophila behaves genetically as an enhancer of trithorax and polycomb (ETP) in displaying bidirectional homeotic phenotypes, suggesting that is required for maintenance of both activation and silencing of Hox genes. There are three murine homologs of Asx called Additional sex combs-like1, 2, and 3. Asxl1 is required for normal adult hematopoiesis; however, its embryonic function is unknown. We used a targeted mouse mutant line Asxl1(tm1Bc) to determine if Asxl1 is required to silence and activate Hox genes in mice during axial patterning. The mutant embryos exhibit simultaneous anterior and posterior transformations of the axial skeleton, consistent with a role for Asxl1 in activation and silencing of Hox genes. Transformations of the axial skeleton are enhanced in compound mutant embryos for the polycomb group gene M33/Cbx2. Hoxa4, Hoxa7, and Hoxc8 are derepressed in Asxl1(tm1Bc) mutants in the antero-posterior axis, but Hoxc8 expression is reduced in the brain of mutants, consistent with Asxl1 being required both for activation and repression of Hox genes. We discuss the genetic and molecular definition of ETPs, and suggest that the function of Asxl1 depends on its cellular context. |
| | |
Authors:
|
C L Fisher; I Lee; S Bloyer; S Bozza; J Chevalier; A Dahl; C Bodner; C D Helgason; J L Hess; R K Humphries; H W Brock |
Related Documents
:
|
9541203 - Patterning of the murine dentition by homeobox genes. 9628823 - Cloning, characterization, and mapping of the mouse homeobox gene hmx1. 16112883 - Molecular evolution of the transcription factor leafy in brassicaceae. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-10-13 |
Journal Detail:
|
Title: Developmental biology Volume: 337 ISSN: 1095-564X ISO Abbreviation: Dev. Biol. Publication Date: 2010 Jan |
Date Detail:
|
Created Date: 2009-11-27 Completed Date: 2009-12-15 Revised Date: 2011-08-01 |
Medline Journal Info:
|
Nlm Unique ID: 0372762 Medline TA: Dev Biol Country: United States |
Other Details:
|
Languages: eng Pagination: 9-15 Citation Subset: IM |
Affiliation:
|
Department of Zoology, University of British Columbia, 2350 Health Sciences Mall, Vancouver, British Columbia V6T1Z3, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Animals, Newborn Bone and Bones / abnormalities* DNA-Binding Proteins / genetics Female Mice Mice, Inbred C57BL Mutation Phenotype Pregnancy Repressor Proteins / genetics, physiology* Spine / abnormalities |
| Grant Support | |
ID/Acronym/Agency:
|
R01 CA078815-03/CA/NCI NIH HHS; R01 CA092251-11/CA/NCI NIH HHS; R01-CA-0078815/CA/NCI NIH HHS; //Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
|
0/Asxl1 protein, mouse; 0/DNA-Binding Proteins; 0/Hoxa4 protein, mouse; 0/Repressor Proteins; 0/polycomb group proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Maternally-inherited Grb10 reduces placental size and efficiency.
Next Document: Held under arrest: Many mature albino RPE cells display polyploidal features consistent with abnorma...