| Additional diagnostic value of (18)F-FDG PET-CT in detecting retropharyngeal nodal metastases. | |
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MedLine Citation:
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PMID: 19861203 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This study investigated whether preoperative (18)fluorine-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) scanning improved the diagnosis of retropharyngeal lymph node (RPLN) metastasis in patients with head and neck squamous cell carcinoma (HNSCC) relative to conventional imaging alone. STUDY DESIGN: Case series with chart review. SETTING: University hospital cancer center. SUBJECTS AND METHODS: Sixty-three patients with HNSCC underwent RPLN dissection in accordance with our indications and were subsequently divided into two groups: CT/magnetic resonance imaging (MRI) only (group A, n = 33) and CT/MRI with PET-CT (group B, n = 30). The preoperative radiological findings of each group were compared with the RPLN histopathologic findings, which served as the standard of reference. RESULTS: RPLN metastasis was confirmed histopathologically in 17 of 63 patients (27.0%): eight from group A and nine from group B. With the additional use of PET-CT in group B, the sensitivity (88.9%), specificity (85.7%), and accuracy (86.7%) were higher than the respective values in group A (62.5%, 60.0%, and 60.6%). The positive and negative predictive values for group B (72.7% and 94.7%, respectively) were also higher than those for group A (33.3% and 83.3%, respectively). False-positive results were obtained in 10 patients from group A and three patients from B; false-negative findings occurred in three patients from group A and one patient from group B. The predictive power of the radiological findings was statistically significant in group B (P = 0.0017), with an odds ratio of 47.987 (95% confidence interval, 4.3-535.0). CONCLUSION: (18)F-FDG PET-CT, when used in combination with CT/MRI, increases diagnostic efficacy in the detection of RPLN metastases and may therefore be useful in screening high-risk patients. |
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Authors:
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Hyung Ro Chu; Jin Hwan Kim; Dae Young Yoon; Hee Sung Hwang; Young-Soo Rho |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery Volume: 141 ISSN: 1097-6817 ISO Abbreviation: Otolaryngol Head Neck Surg Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-28 Completed Date: 2009-11-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8508176 Medline TA: Otolaryngol Head Neck Surg Country: United States |
Other Details:
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Languages: eng Pagination: 633-8 Citation Subset: IM |
Affiliation:
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Department of Otorhinolaryngology-Head and Neck Surgery, Ilsong Memorial Institute of Head and Neck Cancer, Hallym University Medical Center, College of Medicine, Kangdong-Gu, Seoul, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Carcinoma, Squamous Cell / diagnosis, radionuclide imaging* Female Fluorodeoxyglucose F18 / diagnostic use Head and Neck Neoplasms / radionuclide imaging* Humans Lymphatic Metastasis / diagnosis, radionuclide imaging* Magnetic Resonance Imaging Male Middle Aged Positron-Emission Tomography* Retroperitoneal Neoplasms / diagnosis, radionuclide imaging* Sensitivity and Specificity Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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