Document Detail


Additional bioactive Lyso-PAF congeners from the sponge Spirastrella abata.
MedLine Citation:
PMID:  11325244     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A known (1) and four new (2--5) lyso-PAF (platelet activating factor) derivatives were isolated from the sponge Spirastrella abata. Two of them are unprecedented in having a methoxy group at C-2'. The structures have been determined by combined spectroscopic methods. Their inhibitory effect on the biosynthesis of cholesterol and cytotoxicity against human solid tumor cell lines are reported.
Authors:
N Alam; B H Bae; J Hong; C O Lee; B A Shin; K S Im; J H Jung
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of natural products     Volume:  64     ISSN:  0163-3864     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-30     Completed Date:  2001-07-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  533-5     Citation Subset:  IM    
Affiliation:
College of Pharmacy, Pusan National University, Pusan 609-735, Korea.
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MeSH Terms
Descriptor/Qualifier:
Animals
Magnetic Resonance Spectroscopy
Mass Spectrometry
Platelet Activating Factor / analogs & derivatives*,  chemistry,  isolation & purification*
Porifera
Chemical
Reg. No./Substance:
0/O-deacetyl platelet activating factor; 0/Platelet Activating Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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