| Additional benefits of first trimester screening. | |
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MedLine Citation:
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PMID: 16533655 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The goal of first trimester screening for aneuploidy is to provide patients their risk assessment for fetal Down syndrome. Nonetheless, it has been noted that combined screening offers physicians and patients other important pregnancy information. For example, first trimester ultrasound results in accurate pregnancy dating and enables the early diagnosis of multiple gestations during the period when amnionicity and chorionicity is best discerned. It also detects a limited number of fetal anatomical abnormalities, affording patients time to make decisions regarding the management of their pregnancies. A cystic hygroma, one of the most powerful ultrasound markers for fetal aneuploidy, can be detected on first trimester ultrasound. An enlarged nuchal translucency may identify fetuses at risk for other adverse outcomes and for congenital heart defects. In addition, abnormal first trimester serum markers are associated with adverse pregnancy outcomes, and knowledge of these abnormalities may help with patient counseling and management. |
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Authors:
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Mary E D'Alton; Jane Cleary-Goldman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Seminars in perinatology Volume: 29 ISSN: 0146-0005 ISO Abbreviation: Semin. Perinatol. Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2006-03-14 Completed Date: 2006-08-18 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7801132 Medline TA: Semin Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 405-11 Citation Subset: IM |
Affiliation:
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Columbia University Medical Center, New York, NY 10032, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aneuploidy Chorionic Gonadotropin, beta Subunit, Human / blood Congenital Abnormalities / ultrasonography Down Syndrome / diagnosis Female Gestational Age* Heart Defects, Congenital / ultrasonography Humans Lymphangioma, Cystic / ultrasonography Nuchal Translucency Measurement Pregnancy Pregnancy Trimester, First Pregnancy, Multiple Pregnancy-Associated Plasma Protein-A / analysis Prenatal Diagnosis* Risk Factors Ultrasonography, Prenatal |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin, beta Subunit, Human; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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