Document Detail

Additional benefits of first trimester screening.
MedLine Citation:
PMID:  16533655     Owner:  NLM     Status:  MEDLINE    
The goal of first trimester screening for aneuploidy is to provide patients their risk assessment for fetal Down syndrome. Nonetheless, it has been noted that combined screening offers physicians and patients other important pregnancy information. For example, first trimester ultrasound results in accurate pregnancy dating and enables the early diagnosis of multiple gestations during the period when amnionicity and chorionicity is best discerned. It also detects a limited number of fetal anatomical abnormalities, affording patients time to make decisions regarding the management of their pregnancies. A cystic hygroma, one of the most powerful ultrasound markers for fetal aneuploidy, can be detected on first trimester ultrasound. An enlarged nuchal translucency may identify fetuses at risk for other adverse outcomes and for congenital heart defects. In addition, abnormal first trimester serum markers are associated with adverse pregnancy outcomes, and knowledge of these abnormalities may help with patient counseling and management.
Mary E D'Alton; Jane Cleary-Goldman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Seminars in perinatology     Volume:  29     ISSN:  0146-0005     ISO Abbreviation:  Semin. Perinatol.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2006-03-14     Completed Date:  2006-08-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7801132     Medline TA:  Semin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  405-11     Citation Subset:  IM    
Columbia University Medical Center, New York, NY 10032, USA.
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MeSH Terms
Chorionic Gonadotropin, beta Subunit, Human / blood
Congenital Abnormalities / ultrasonography
Down Syndrome / diagnosis
Gestational Age*
Heart Defects, Congenital / ultrasonography
Lymphangioma, Cystic / ultrasonography
Nuchal Translucency Measurement
Pregnancy Trimester, First
Pregnancy, Multiple
Pregnancy-Associated Plasma Protein-A / analysis
Prenatal Diagnosis*
Risk Factors
Ultrasonography, Prenatal
Reg. No./Substance:
0/Chorionic Gonadotropin, beta Subunit, Human; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A

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