| Additional benefit of (18)F-fluorodeoxyglucose integrated positron emission tomography/computed tomography in the staging of oesophageal cancer. | |
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MedLine Citation:
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PMID: 20821013 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: (18)F-fluorodeoxyglucose positron emission tomography (FDG PET) has been shown to improve the accuracy of staging in oesophageal cancer. We assessed the benefit of PET/CT over conventional staging and determined if tumour histology had any significant impact on PET/CT findings. METHODS: A retrospective cohort study, reviewing the results from 200 consecutive patients considered suitable for radical treatment, undergoing routine PET/CT staging comparing the results from CT and endoscopic ultrasound, as well as multi-disciplinary team records. Adenocarcinoma and squamous cell carcinoma were compared for maximum Standardised Uptake Value (SUV(max)), involvement of local lymph nodes and distant metastases. RESULTS: PET/CT provided additional information in 37 patients (18.5%) and directly altered management in 34 (17%): 22 (11%) were upstaged; 15 (7.5%) were downstaged, 12 of whom (6%) received radical treatment. There were 11 false negatives (5.5%) and 1 false positive (0.5%). SUV(max) was significantly lower for adenocarcinoma than squamous cell carcinoma (median 9.1 versus 13.5, p = 0.003). CONCLUSIONS: Staging with PET/CT offers additional benefit over conventional imaging and should form part of routine staging for oesophageal cancer. Adenocarcinoma and squamous cell carcinoma display significantly different FDG-avidity. |
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Authors:
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R S Gillies; M R Middleton; N D Maynard; K M Bradley; F V Gleeson |
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Publication Detail:
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Type: Journal Article Date: 2010-09-04 |
Journal Detail:
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Title: European radiology Volume: 21 ISSN: 1432-1084 ISO Abbreviation: Eur Radiol Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9114774 Medline TA: Eur Radiol Country: Germany |
Other Details:
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Languages: eng Pagination: 274-80 Citation Subset: IM |
Affiliation:
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Department of Medical Oncology, Oxford Cancer and Haematology Centre, Churchill Hospital, Oxford, OX3 7LJ, UK, rgillies@doctors.org.uk. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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