| Additional value of PET-CT in staging of clinical stage IIB and III breast cancer. | |
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MedLine Citation:
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PMID: 21070439 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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To evaluate retrospectively the accuracy of integrated PET/CT, against PET, CT, or conventional staging in breast cancer. Seventy consecutive biopsy proven clinical stage IIB and III breast cancer patients were included. Descriptive statistics of integrated PET/CT for the primary tumor, nodal status and metastasis detection were compared to PET, CT with contrast, and conventional staging (biochemistry, chest X-ray, liver ultrasound, and bone scintigraphy). Sensitivity of PET/CT for primary tumor and nodal status was 97.1% and 62.5%, respectively. Specificity and negative predictive value for nodal status were 100% and 66.6%, respectively. The values for conventional staging for nodal involvement were 100% and 85.7% with a sensitivity of 87.5%. PET/CT showed metastatic disease in seven women despite normal conventional staging. PET/CT is able to visualize most clinical stage IIB and III primary breast cancers. PET/CT is superior to conventional staging for detecting internal mammary chain nodes and metastatic disease, but not for axillary staging. Future studies will have to test whether therapy adjustment based on PET/CT has the potential to improve survival. |
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Authors:
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Isabelle Segaert; Felix Mottaghy; Sarah Ceyssens; Walter De Wever; Sigrid Stroobants; Chantal Van Ongeval; Eric Van Limbergen; Hans Wildiers; Robert Paridaens; Ignace Vergote; Marie-Rose Christiaens; Patrick Neven |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The breast journal Volume: 16 ISSN: 1524-4741 ISO Abbreviation: Breast J Publication Date: 2010 Nov-Dec |
Date Detail:
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Created Date: 2010-11-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9505539 Medline TA: Breast J Country: United States |
Other Details:
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Languages: eng Pagination: 617-24 Citation Subset: IM |
Copyright Information:
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© 2010 Wiley Periodicals, Inc. |
Affiliation:
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Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium. isabellesegaert@hotmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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