Document Detail

Additional first-trimester ultrasound markers.
MedLine Citation:
PMID:  20638573     Owner:  NLM     Status:  MEDLINE    
The first trimester (11-13 +6 weeks) ultrasound examination is useful for several reasons: determination of an accurate date of confinement, diagnostic purposes, and screening for fetal defects. Nuchal translucency measurement combined with maternal serum markers (free b-human chorionic gonadotropin and pregnancy-associated plasma protein A) is the mainstay of first-trimester screening for chromosomal defects. However, over the past decade additional ultrasound markers have been developed that improve the performance of this type of screening. The novel markers include evaluation of the nasal bone, fronto-maxillary angle measurement, and Doppler evaluations of the blood flow across the tricuspid valve and in the ductus venosus.
J Sonek; K Nicolaides
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinics in laboratory medicine     Volume:  30     ISSN:  1557-9832     ISO Abbreviation:  Clin. Lab. Med.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-07-19     Completed Date:  2010-11-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100174     Medline TA:  Clin Lab Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  573-92     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Wright State University, Dayton, OH, USA.
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MeSH Terms
Biological Markers / analysis
Down Syndrome / diagnosis,  ultrasonography
Fetal Heart / ultrasonography
Nasal Bone / embryology,  ultrasonography
Nuchal Translucency Measurement
Pregnancy Trimester, First*
Ultrasonography, Prenatal / methods*,  standards
Reg. No./Substance:
0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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