Document Detail


Addition of a low dose of rimonabant to orlistat therapy decreases weight gain and reduces adiposity in dietary obese rats.
MedLine Citation:
PMID:  22524969     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The aim of the current study was to explore if the addition of a sub-effective dose of rimonabant (1 mg/kg) to orlistat would produce a better impact in treating diet-induced obesity in rats in comparison to monotherapy with orlistat. Male rats were classified into five groups. Rats were fed either low-fat diet (LFD) or high-fat diet (HFD) for four months. The HFD-fed rats received daily treatment with vehicle, orlistat (10 mg/kg), rimonabant (1 mg/kg) or a combination of both drugs. Fasting blood glucose, serum insulin, leptin and adiponectin were measured. Liver and adiposity indices were also calculated. Liver and adipose tissues were processed for histological examination. In the current study, HFD-vehicle treated rats showed increases in the cumulative food intake, body weight as well as liver and adiposity indices. HFD-vehicle group showed deteriorated liver function and abnormal lipid profile. In addition, insulin resistance and serum leptin were increased whereas; serum adiponectin was decreased in HFD-vehicle group. Monotherapy with orlistat or its combination with rimonabant improved the above-mentioned parameters. The addition of the current low sub-effective dose of rimonabant to orlistat therapy ameliorated HFD-induced obesity to a much greater extent than monotherapy with orlistat. This combination showed better weight control and metabolic profile compared to the per se effect of orlistat. Therefore, the current study encourage reassessing the use a low dose of rimonabant to potentiate the effect of orlistat in the clinical management of obesity if proper clinical safety data are available. © 2012 The Authors Clinical and Experimental Pharmacology and Physiology © 2012 Blackwell Publishing Asia Pty Ltd.
Authors:
Sawsan Zaitone; Soha Essawy
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-23
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  -     ISSN:  1440-1681     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors Clinical and Experimental Pharmacology and Physiology © 2012 Blackwell Publishing Asia Pty Ltd.
Affiliation:
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, 41522, Egypt.
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