Document Detail

Addition of glucose to an oral fat load reduces postprandial free fatty acids and prevents the postprandial increase in complement component 3.
MedLine Citation:
PMID:  14985229     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Elevated fasting plasma concentrations of complement component 3 (C3) are associated with elevated fasting and postprandial triacylglycerol concentrations, insulin resistance, obesity, and coronary artery disease. C3 is the central component of the complement system and the precursor of acylation-stimulating protein (ASP). Insulin and ASP are principal determinants of free fatty acid (FFA) trapping by adipose tissue.
OBJECTIVE: Because controversy exists concerning postprandial changes in C3 and because meal composition may influence complement activation, we studied postprandial lipemia in relation to changes in plasma C3.
DESIGN: After an overnight fast, 6 healthy men ( +/- SD age: 23 +/- 2 y) underwent 4 oral liquid challenges: fat (50 g/m(2) body surface), glucose (37.5 g/m(2)), fat and glucose (mixed test), and water (as a control test) in a random, crossover design.
RESULTS: Plasma ASP concentrations did not change postprandially in any test. Changes in C3 concentration were observed only after the fat challenge: elevated concentrations occurred between 1 and 3 h, and a maximum increase of 11% occurred at 2 h (P = 0.05). Postprandial triacylglycerolemia did not differ significantly between the fat and mixed tests. The FFA response after the fat challenge was the highest of all the tests (P < 0.05 for all comparisons) and was accompanied by an increase in ketone bodies (maximum at 6 h); this increase did not occur after the mixed test, which suggests less hepatic FFA delivery.
CONCLUSIONS: When glucose is added to an oral fat load, the postprandial FFA response is reduced, and the fat-specific increase in C3 is prevented. After ingestion of fat without glucose, the lack of insulin response may lead to C3-mediated peripheral FFA trapping, which probably serves as a backup system in case of insufficient or inefficient insulin-dependent FFA trapping.
Antonie J van Oostrom; Hans van Dijk; Caroline Verseyden; Allan D Sniderman; Katherine Cianflone; Ton J Rabelink; Manuel Castro Cabezas
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  79     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-02-26     Completed Date:  2004-03-30     Revised Date:  2013-08-23    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  510-5     Citation Subset:  AIM; IM    
Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, Netherlands.
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MeSH Terms
Area Under Curve
Blood Proteins / metabolism
Complement Activation
Complement C3 / metabolism*
Complement C3a* / analogs & derivatives*
Cross-Over Studies
Dietary Fats / administration & dosage*,  metabolism
Fatty Acids, Volatile / metabolism*
Glucose / administration & dosage*,  metabolism
Insulin / blood
Insulin Resistance
Ketone Bodies / metabolism
Obesity / blood
Postprandial Period / physiology*
Triglycerides / blood
Reg. No./Substance:
0/Blood Proteins; 0/Complement C3; 0/Dietary Fats; 0/Fatty Acids, Volatile; 0/Insulin; 0/Ketone Bodies; 0/Triglycerides; 0/complement C3a, des-Arg-(77)-; 50-99-7/Glucose; 80295-42-7/Complement C3a

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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