| Addition of candesartan to angiotensin converting enzyme inhibitor therapy in patients with chronic heart failure does not reduce levels of oxidative stress. | |
| | |
MedLine Citation:
|
PMID: 11959049 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Angiotensin II exerts a number of harmful effects in patients with chronic heart failure (CHF) and, through an increase in oxidative stress, is thought to be critical in the development of endothelial dysfunction. Angiotensin II may be elevated in CHF despite treatment with angiotensin converting enzyme (ACE) inhibitors, producing a rationale for adjunctive angiotensin receptor blockade. We investigated whether the addition of angiotensin antagonism to ACE inhibition would reduce oxidative stress and improve endothelial function and exercise tolerance in patients with chronic heart failure. METHODS AND RESULTS: Twenty-eight heart failure patients, who were on stable ACE inhibitor therapy, were randomised to receive adjunctive therapy with candesartan or placebo. Plasma lipid-derived free radicals, TBARS and neutrophil O2-generation, markers of oxidative stress, were measured in venous blood. Arterial endothelial function was assessed as the response of the brachial artery to flow-related shear stress. Exercise capacity was determined by cardiopulmonary exercise testing. Compared with placebo, candesartan had no effect on changes in lipid derived free radicals (-0.1+/-1.2 vs. -0.1+/-1.0 units, respectively, P=NS), TBARS (-2.2+/-1.1 vs. -2.6+/-2.2 micromol/l, respectively, P=NS) or neutrophil O2-generating capacity (-7.3+/-5.1 vs. -8.4+/-7.9 mV/5x10(5) neutrophils, respectively, P=NS). There was no effect on changes in brachial artery flow-mediated dilatation (0.5+/-1.0 vs. 0.8+/-1.3%, respectively, P=NS) nor peak VO2 (1.6+/-0.7 ml/kg per min vs. 1.8+/-0.6 ml/kg per min; P=NS). CONCLUSION: The addition of the candesartan to ACE inhibitor therapy had no effect on oxidative stress and did not improve endothelial function or exercise capacity in patients with CHF. |
| | |
Authors:
|
Gethin R Ellis; Angus K Nightingale; Daniel J Blackman; Richard A Anderson; Catherine Mumford; Graham Timmins; Derek Lang; Simon K Jackson; Michael D Penney; Malcolm J Lewis; Michael P Frenneaux; Jayne Morris-Thurgood |
Related Documents
:
|
14658999 - Does physical training increase insulin sensitivity in chronic heart failure patients? 9613799 - Relative burst amplitude in human muscle sympathetic nerve activity: a sensitive indica... 10588589 - Ventilatory assistance improves exercise endurance in stable congestive heart failure. 9688429 - Percent achieved of predicted peak exercise oxygen uptake and kinetics of recovery of o... 18473269 - Impact of cardiac resynchronisation therapy on adaptation of circulatory and respirator... 16186059 - Ischemic etiology of heart failure identifies patients with more severely impaired exer... 7369979 - Retinal studies at 446 torr in a hypobaric chamber. 17123319 - The repeatability of submaximal endurance exercise testing in cystic fibrosis. 20416959 - The long-term benefits of a multi-component exercise intervention to balance and mobili... |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: European journal of heart failure Volume: 4 ISSN: 1388-9842 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2002 Mar |
Date Detail:
|
Created Date: 2002-04-17 Completed Date: 2002-05-22 Revised Date: 2011-06-08 |
Medline Journal Info:
|
Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 193-9 Citation Subset: IM |
Affiliation:
|
Department of Cardiology, Royal Glamorgan Hospital, Llantrisant, Rhondda Cynon Taf, UK. gethin.ellis@pr-tr.nhs.wales.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Angiotensin-Converting Enzyme Inhibitors / therapeutic use* Antihypertensive Agents / therapeutic use* Benzimidazoles / therapeutic use* Blood Pressure / drug effects Brachial Artery / chemistry Chronic Disease Drug Therapy, Combination Endothelium, Vascular / drug effects Exercise Tolerance / drug effects Female Follow-Up Studies Heart Failure / drug therapy* Heart Rate / drug effects Humans Lipid Peroxidation / drug effects Male Middle Aged Natriuretic Peptide, Brain / blood, drug effects Oxidative Stress / drug effects* Stroke Volume / drug effects Tetrazoles / therapeutic use* Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Benzimidazoles; 0/Tetrazoles; 114471-18-0/Natriuretic Peptide, Brain; 139481-59-7/candesartan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: GH-independent cardiotropic activities of hexarelin in patients with severe left ventricular dysfunc...
Next Document: Effect of dofetilide on QT dispersion and the prognostic implications of changes in QT dispersion fo...