| Addition of an anabolic steroid to strength training promotes muscle strength in the nonparetic lower limb of poststroke hemiplegia patients. | |
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MedLine Citation:
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PMID: 20707637 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this prospective observer-blinded open-label nonrandomized controlled trial, 25 inpatients with hemiplegia 1-8 months after stroke were assigned to an anabolic androgenic steroid (AAS; n = 14) or a control (n = 11) group: the former received 100 mg metenolone enanthate by intramuscular injection once a week for 6 weeks along with rehabilitation therapy including muscle strength training of the nonparetic lower limb, which consisted of 100 repetitions of isokinetic reciprocal knee extension/flexion (60 degrees /s) on a dynamometer once a day for 5 days a week over 6 weeks, and the latter received rehabilitation therapy alone. The maximal peak torque of the nonparetic lower limb, including the isokinetic (60 degrees /s, 120 degrees /s, and 180 degrees /s), isotonic, and isometric muscle strength of knee extension/flexion, measured every 2 weeks, was compared with the baseline values. Significant increases in peak torque were seen at 2 weeks in 9 of the 10 conditions and at 6 weeks in 8 of the 10 conditions tested for the AAS group but in only 1 and 5 conditions for the control group, respectively. While no contraindications for AAS were encountered, the combination of AAS and muscle strength training tended to have a positive effect on muscle strength after stroke. |
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Authors:
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Megumi Shimodozono; Kazumi Kawahira; Atsuko Ogata; Seiji Etoh; Nobuyuki Tanaka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The International journal of neuroscience Volume: 120 ISSN: 1563-5279 ISO Abbreviation: Int. J. Neurosci. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-16 Completed Date: 2010-12-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0270707 Medline TA: Int J Neurosci Country: England |
Other Details:
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Languages: eng Pagination: 617-24 Citation Subset: IM |
Affiliation:
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Department of Rehabilitation and Physical Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. rihakoza@m2.kufm.kagoshima-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anabolic Agents / therapeutic use* Controlled Clinical Trials as Topic Female Hemiplegia / rehabilitation* Humans Knee Joint / physiology Lower Extremity / physiopathology* Male Middle Aged Muscle Strength / drug effects* Muscle Strength Dynamometer Resistance Training / methods* Stroke / physiopathology, rehabilitation* |
| Chemical | |
Reg. No./Substance:
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0/Anabolic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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