Document Detail

Addition of aerobic exercise to a weight loss program increases BMD, with an associated reduction in inflammation in overweight postmenopausal women.
MedLine Citation:
PMID:  19280097     Owner:  NLM     Status:  MEDLINE    
Increased inflammation and weight loss are associated with a reduction in bone mineral density (BMD). Aerobic exercise may minimize the loss of bone and weight loss may contribute to a decrease in cytokines. We tested the hypothesis that aerobic exercise in combination with a weight loss program would decrease circulating concentrations of inflammatory markers, thus mediating changes in BMD. This was a nonrandomized controlled trial. Eighty-six overweight and obese postmenopausal women (50-70 years of age; BMI, 25-40 kg/m(2)) participated in a weight loss (WL; n = 40) or weight loss plus walking (WL + AEX; n = 46) program. Outcome measures included BMD and bone mineral content of the femoral neck and lumbar spine measured by dual energy X-ray absorptiometry, interleukin-6, tumor necrosis factor-alpha, soluble receptors of IL-6, and TNF-alpha (sTNFR1 and sTNFR2; receptors in a subset of the population), VO(2) max, fat mass, and lean mass. Weight decreased in the WL (p < 0.001) and WL + AEX (p < 0.001) groups. VO(2) max increased (p < 0.001) after WL + AEX. There was a 2% increase in femoral neck BMD in the WL + AEX group (p = 0.001), which was significantly different from the WL group. The change in sTNFR1 was significantly associated with the change in femoral neck BMD (p < 0.05). The change in VO(2) max was an independent predictor of the change in femoral neck BMD. Our findings suggest that the addition of aerobic exercise is recommended to decrease inflammation and increase BMD during weight loss in overweight postmenopausal women.
Natalie E Silverman; Barbara J Nicklas; Alice S Ryan
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2009-03-11
Journal Detail:
Title:  Calcified tissue international     Volume:  84     ISSN:  1432-0827     ISO Abbreviation:  Calcif. Tissue Int.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-31     Completed Date:  2009-06-08     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  7905481     Medline TA:  Calcif Tissue Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  257-65     Citation Subset:  IM    
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MeSH Terms
Biological Markers / blood
Bone Density*
Caloric Restriction
Combined Modality Therapy
Cytokines / blood
Femur Neck / radiography
Inflammation / therapy
Lumbar Vertebrae / radiography
Middle Aged
Osteoporosis / physiopathology,  prevention & control*
Overweight / physiopathology,  therapy*
Receptors, Cytokine / blood
Treatment Outcome
Grant Support
K01-AG-00747/AG/NIA NIH HHS; P01-DK-072488/DK/NIDDK NIH HHS; P30 DK072488/DK/NIDDK NIH HHS; P30 DK072488-01/DK/NIDDK NIH HHS; R01 AG018408/AG/NIA NIH HHS; R01 AG018408-05/AG/NIA NIH HHS; R01 AG019310/AG/NIA NIH HHS; R01 AG019310-05/AG/NIA NIH HHS; R01 NR-03514/NR/NINR NIH HHS; R01 NR003514-05/NR/NINR NIH HHS; R01-AG-019310/AG/NIA NIH HHS; R01-AG-18408/AG/NIA NIH HHS; R29 AG014066/AG/NIA NIH HHS; R29 AG014066-06/AG/NIA NIH HHS; R29-AG-14066/AG/NIA NIH HHS; T32 AG-00219/AG/NIA NIH HHS; T32 AG000219/AG/NIA NIH HHS; T32 AG000219-15/AG/NIA NIH HHS
Reg. No./Substance:
0/Biological Markers; 0/Cytokines; 0/Receptors, Cytokine

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