Document Detail

Addition of a 2-month low-dose course of levofloxacin to long-term erythromycin therapy in sinobronchial syndrome.
MedLine Citation:
PMID:  12421239     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We previously reported that a 6-month low-dose course of ofloxacin combined with long-term low-dose erythromycin therapy (EM therapy) was superior to EM therapy alone for sinobronchial syndrome (SBS), especially during the initial 2 months of treatment. However, there was no data as to whether discontinuation of low-dose ofloxacin after 2 months results in symptom relapse. This study was designed to clarify this issue. METHODOLOGY: Twenty-three patients with SBS received a 2-month course of levofloxacin (LVFX) therapy (100 mg once a day) concurrent with a 6-month course of EM therapy (200 mg three times a day) (group A). Eighteen other patients were given the EM therapy alone (group B). Clinical parameters, including quantity of morning sputum, were recorded in a daily symptom diary, and reviewed by each doctor in charge at 2-4 week intervals. RESULTS: The quantity of morning sputum decreased more rapidly in group A than in group B. No relapse of symptoms was recognized after discontinuation of LVFX in group A. CONCLUSIONS: A 2-month low-dose course of LVFX in conjunction with long-term EM therapy may be efficacious for the treatment of SBS, as evidenced by rapid improvement of expectoration without any relapse after LVFX discontinuation.
Masaki Fujimura; Masayuki Mizuguchi; Yasuto Nakatsumi; Keiichi Mizuhashi; Shigeki Sasaki; Masahide Yasui;
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  7     ISSN:  1323-7799     ISO Abbreviation:  Respirology     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-11-07     Completed Date:  2003-03-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  317-24     Citation Subset:  IM    
The Third Department of Internal Medicine, Kanazawa University Hospital, Kanazawa, Japan.
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MeSH Terms
Anti-Bacterial Agents / administration & dosage*
Anti-Infective Agents / administration & dosage*
Bronchiolitis / drug therapy
Bronchitis / drug therapy*
Drug Therapy, Combination
Erythromycin / administration & dosage*
Middle Aged
Ofloxacin / administration & dosage*
Sinusitis / drug therapy*
Treatment Outcome
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Infective Agents; 114-07-8/Erythromycin; 82419-36-1/Ofloxacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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