| Adding to Hans Kuhn's thesis on the emergence of the genetic apparatus: of the Darwinian advantage to be neither too soluble, nor too insoluble, neither too solid, nor completely liquid. | |
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MedLine Citation:
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PMID: 19651497 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A scenario of the origin of the genetic apparatus is described where the surface and physico-chemical properties of lipid bilayers and multilayers of vesicles play a crucial role. Peptides, nucleic acids and lipids are 'collaborating' to bring about a first successful genetic apparatus. Lipidic vesicles acquire new properties through hosting nucleic acids that are transiently but covalently linked to lipophilic peptides. These peptides anchor the associated nucleic acids into the surface of lipidic vesicles. In the interior of such vesicles, within the lipidic bilayer, peptidyl transfers occur that are reminiscent of modern-day ribosomal peptidyl transfer reactions. One can expect that the growing peptides eventually acquire, stepwise and essentially arbitrarily, new functions different from anchoring nucleic acids, such as specific aminoacylation of nucleic acids, template-assisted nucleic acid synthesis, nucleotide deoxygenation and fatty acid synthesis. |
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Authors:
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Peter Strazewski |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-09 |
Journal Detail:
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Title: Colloids and surfaces. B, Biointerfaces Volume: 74 ISSN: 1873-4367 ISO Abbreviation: Colloids Surf B Biointerfaces Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-10-28 Completed Date: 2010-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9315133 Medline TA: Colloids Surf B Biointerfaces Country: Netherlands |
Other Details:
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Languages: eng Pagination: 419-25 Citation Subset: IM |
Affiliation:
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Universit?? de Lyon, F-69622, Lyon, France. strazewski@univ-lyon1.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biogenesis* Fatty Acids / biosynthesis Lipid Bilayers Nucleic Acids / biosynthesis, chemistry Peptides / chemistry Solubility |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Lipid Bilayers; 0/Nucleic Acids; 0/Peptides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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