Document Detail

Adding carbohydrate to a high-fat meal blunts postprandial lipemia in women and reduces meal-derived fatty acids in systemic circulation.
MedLine Citation:
PMID:  18347687     Owner:  NLM     Status:  MEDLINE    
The lipemic response to a meal is an important independent risk factor for the development of cardiovascular disease. The purpose of this study was to determine the effect of adding carbohydrate (CHO) to a fat meal on the bioavailability of ingested fat in different blood lipid fractions in men and women. On two separate occasions, 18 healthy adults (9 women, 9 men) ate either a high-fat meal (0.7 grams fat per kilogram) (FAT), or the same meal with added CHO (1 gram CHO per kilogram) (FAT+CHO) in the morning after a 12 h fast. Both meals were supplemented with [13C]-palmitate (25 Plasma concentrations of triglyceride (TG), fatty acids, insulin, and glucose were measured in blood samples taken hourly from 0 to 8 h after the meal. In addition, we measured TG concentrations in chylomicron (CHYLO-TG) and in very-low-density lipoprotein (VLDL-TG) fractions. The addition of CHO to the fat meal increased plasma glucose and insulin concentrations identically in men and women. In contrast, adding CHO to the fat meal reduced the plasma TG concentration in the 5 h after the meal in women (average 5 h [TG]: 1.27 +/- 0.11 and 1.01 +/- 0.09 mmol.L(-1); p <0.05), but not in men (1.25 +/- 0.23 and 1.24 +/- 0.20 mmol.L(-1)). Despite differences in the lipemic response to the meals between men and women, we found that adding carbohydrate to a fat meal decreased the bioavailability of meal-derived [13C]-palmitate in the systemic fatty acid pool, and decreased the incorporation of [13C]-palmitate into VLDL-TG in both men and women. In summary, adding CHO to a fat meal markedly blunted the plasma TG response in women, but not in men, which may augment the atherogenic potential after each meal in men.
Nicolas D Knuth; David B Remias; Jeffrey F Horowitz
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme     Volume:  33     ISSN:  1715-5312     ISO Abbreviation:  -     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-18     Completed Date:  2008-08-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264333     Medline TA:  Appl Physiol Nutr Metab     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  315-25     Citation Subset:  IM    
Substrate Metabolism Laboratory, Division of Kinesiology, University of Michigan, Ann Arbor, MI 48109-2214, USA.
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MeSH Terms
Blood Glucose / metabolism
Body Composition / physiology
Breath Tests
Chylomicrons / blood
Dietary Carbohydrates / pharmacology*
Dietary Fats / pharmacology*
Fatty Acids / blood*
Insulin / blood
Lipids / blood*
Lipoproteins, VLDL / blood
Palmitates / blood
Postprandial Period / physiology*
Sex Characteristics
Grant Support
Reg. No./Substance:
0/Blood Glucose; 0/Chylomicrons; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Fatty Acids; 0/Lipids; 0/Lipoproteins, VLDL; 0/Palmitates; 11061-68-0/Insulin

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