Document Detail

Addiction modules and programmed cell death and antideath in bacterial cultures.
MedLine Citation:
PMID:  10547685     Owner:  NLM     Status:  MEDLINE    
In bacteria, programmed cell death is mediated through "addiction modules" consisting of two genes. The product of the second gene is a stable toxin, whereas the product of the first is a labile antitoxin. Here we extensively review what is known about those modules that are borne by one of a number of Escherichia coli extrachromosomal elements and are responsible for the postsegregational killing effect. We focus on a recently discovered chromosomally borne regulatable addiction module in E. coli that responds to nutritional stress and also on an antideath gene of the E. coli bacteriophage lambda. We consider the relation of these two to programmed cell death and antideath in bacterial cultures. Finally, we discuss the similarities between basic features of programmed cell death and antideath in both prokaryotes and eukaryotes and the possibility that they share a common evolutionary origin.
H Engelberg-Kulka; G Glaser
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Annual review of microbiology     Volume:  53     ISSN:  0066-4227     ISO Abbreviation:  Annu. Rev. Microbiol.     Publication Date:  1999  
Date Detail:
Created Date:  1999-12-06     Completed Date:  1999-12-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372370     Medline TA:  Annu Rev Microbiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  43-70     Citation Subset:  IM    
Department of Molecular Biology, Hebrew University Hadassah-Medical School, Jerusalem, Israel.
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MeSH Terms
Apoptosis* / genetics,  physiology
Bacterial Proteins / genetics,  physiology
Bacteriophage lambda / genetics*
Escherichia coli / cytology*,  growth & development,  virology
Genes, Bacterial*
Genes, Viral
Plasmids / genetics*
Viral Proteins / genetics,  physiology
Reg. No./Substance:
0/Bacterial Proteins; 0/Viral Proteins

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