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Addiction-like behavior in Drosophila.
MedLine Citation:
PMID:  20798826     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Alcohol abuse is a pervasive problem known to be influenced by genetic factors, yet our understanding of the mechanisms underlying alcohol addiction is far from complete. Drosophila melanogaster has been established as a model for studying the molecular mechanisms that mediate the acute and chronic effects of alcohol. However, the Drosophila model has not yet been extended to include more complex alcohol-related behaviors such as self-administration. We recently established a paradigm to characterize ethanol consumption and preference in flies. We demonstrated that flies prefer to consume ethanol-containing food over regular food, and this preference exhibits several features of alcohol addiction: flies increase ethanol consumption over time, they consume ethanol to pharmacologically relevant concentrations, they will overcome an aversive stimulus in order to consume ethanol, and they exhibit relapse after a period of ethanol deprivation. Thus, ethanol preference in flies provides a new model for studying important aspects of addiction and their underlying mechanisms. One mutant that displayed decreased ethanol preference, krasavietz, may represent a first step toward uncovering those mechanisms.
Authors:
Anita V Devineni; Ulrike Heberlein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Communicative & integrative biology     Volume:  3     ISSN:  1942-0889     ISO Abbreviation:  Commun Integr Biol     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-08-27     Completed Date:  2011-07-14     Revised Date:  2014-10-09    
Medline Journal Info:
Nlm Unique ID:  101478473     Medline TA:  Commun Integr Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  357-9     Citation Subset:  -    
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