| Addicted to Myc--but why? | |
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MedLine Citation:
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PMID: 21536730 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many tumors continuously depend on the initiating oncogenes, but whether this extends to their downstream targets is unclear. In this issue of Genes & Development, Sodir and colleagues (pp. 907-916) demonstrate an essential role for endogenous Myc proteins in maintaining the tumor microenvironment, providing an unexpected molecular explanation for addiction to Myc. |
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Authors:
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Björn von Eyss; Martin Eilers |
Publication Detail:
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Type: Comment; Journal Article |
Journal Detail:
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Title: Genes & development Volume: 25 ISSN: 1549-5477 ISO Abbreviation: Genes Dev. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-03 Completed Date: 2011-06-24 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 8711660 Medline TA: Genes Dev Country: United States |
Other Details:
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Languages: eng Pagination: 895-7 Citation Subset: IM |
Affiliation:
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Theodor Boveri Institute, Biocenter, University of Würzburg, Würzburg 97074, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, Polyomavirus Transforming / metabolism Apoptosis Gene Expression Regulation, Neoplastic Genes, myc / genetics Humans Neoplasms / blood supply, physiopathology* Neovascularization, Pathologic / genetics, metabolism Proto-Oncogene Proteins c-myc / genetics, metabolism* Tumor Microenvironment / physiology |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Polyomavirus Transforming; 0/Proto-Oncogene Proteins c-myc |
| Comments/Corrections | |
Comment On:
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Genes Dev. 2011 May 1;25(9):907-16
[PMID:
21478273
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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