Document Detail

Added value and diagnostic performance of intratumoral susceptibility signals in the differential diagnosis of solitary enhancing brain lesions: preliminary study.
MedLine Citation:
PMID:  19461062     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: It has been reported that high-resolution susceptibility-weighted imaging (HR-SWI) is a promising tool for assessing brain tumor characterization noninvasively. The purpose of this study was to determine the added value and diagnostic performance of HR-SWI for differentiating solitary enhancing brain lesions (SELs) by assessing intratumoral susceptibility signals (ITSSs). MATERIALS AND METHODS: Sixty-four consecutive patients with SELs, without previous surgery, were retrospectively reviewed. We performed 2 consensus reviews, by using conventional MR images alone and with adjunctive HR-SWI. We applied an ITSS grading system based on the degree of the ITSS. Then, we compared the presence and grade of the ITSSs among specific pathologic types of SELs. RESULTS: Two observers diagnosed tumor pathology accurately in 43 (67%) of 64 SELs after reviewing the conventional images alone and 50 (78%) of 64 SELs after reviewing the adjunctive HR-SWI (P = .016, McNemar test). ITSSs were seen in 25 (100%) of 25 glioblastoma multiformes (GBMs), in 2 (40%) of 5 anaplastic astrocytomas, and in 11 (73%) of 15 metastatic tumors. Although the ITSSs were unable to distinguish between GBMs and solitary metastatic tumors, differentiation between GBMs and solitary metastatic tumors was achieved (P = .01) by using a high ITSS degree (grade 3). Moreover, the ITSSs could discriminate high-grade gliomas from lymphomas and nontumorous lesions with a specificity of 100% (P < .0001). CONCLUSIONS: The use of ITSSs on HR-SWIs significantly improves the accuracy for the differential diagnosis of SELs compared with the use of conventional MR imaging alone.
H S Kim; G-H Jahng; C W Ryu; S Y Kim
Publication Detail:
Type:  Journal Article     Date:  2009-05-20
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  30     ISSN:  1936-959X     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-09-14     Completed Date:  2009-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1574-9     Citation Subset:  IM    
Department of Diagnostic Radiology, Ajou University School of Medicine, Suwon, Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Brain / pathology*
Brain Neoplasms / diagnosis*
Diagnosis, Differential
Image Enhancement / methods*
Magnetic Resonance Imaging / methods*
Middle Aged
Observer Variation
Pilot Projects
Reproducibility of Results
Sensitivity and Specificity
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Conebeam CT of the head and neck, part 2: clinical applications.
Next Document:  Impact of intra-arterial injection parameters on arterial, capillary, and venous time-concentration ...