| Added diagnostic value of CSF biomarkers in differential dementia diagnosis. | |
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MedLine Citation:
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PMID: 19150153 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study aimed to investigate whether cerebrospinal fluid (CSF) biomarkers could have helped the clinician in differential dementia diagnosis in case of clinically ambiguous diagnoses, as compared to autopsy-confirmed dementia diagnosis as gold standard. Twenty-two patients of our autopsy-confirmed dementia population totalling 157 patients had an ambiguous clinical diagnosis at CSF sampling and were included in statistical analysis. CSF levels of β-amyloid peptide (Aβ(1-42)), total tau protein (T-tau) and tau phosphorylated at threonine 181 (P-tau(181P)) were determined. A biomarker-based model was applied to discriminate between AD and NON-AD dementias. AD and NON-AD patients showed no significant differences in Aβ(1-42) and T-tau concentrations, whereas P-tau(181P) concentrations were significantly higher in AD compared to NON-AD patients. The biomarker-based diagnostic model correctly classified 18 of 22 (82%) patients with clinically ambiguous diagnoses. Using a biomarker-based model in patients with clinically ambiguous diagnoses, a correct diagnosis would have been established in the majority of autopsy-confirmed AD and NON-AD cases, indicating that biomarkers have an added diagnostic value in cases with ambiguous clinical diagnoses. |
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Authors:
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Nathalie Le Bastard; Jean-Jacques Martin; Eugeen Vanmechelen; Hugo Vanderstichele; Peter Paul De Deyn; Sebastiaan Engelborghs |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-01-15 |
Journal Detail:
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Title: Neurobiology of aging Volume: 31 ISSN: 1558-1497 ISO Abbreviation: Neurobiol. Aging Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-09-27 Completed Date: 2011-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8100437 Medline TA: Neurobiol Aging Country: United States |
Other Details:
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Languages: eng Pagination: 1867-76 Citation Subset: IM |
Copyright Information:
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Copyright © 2008 Elsevier Inc. All rights reserved. |
Affiliation:
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Reference Center for Biological Markers of Memory Disorders, Laboratory of Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alzheimer Disease / cerebrospinal fluid, diagnosis* Amyloid beta-Peptides / cerebrospinal fluid*, diagnostic use Biological Markers / cerebrospinal fluid Case-Control Studies Dementia / cerebrospinal fluid, diagnosis* Diagnosis, Differential Female Humans Male Models, Biological Peptide Fragments / cerebrospinal fluid*, diagnostic use Sensitivity and Specificity tau Proteins / cerebrospinal fluid*, diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Amyloid beta-Peptides; 0/Biological Markers; 0/Peptide Fragments; 0/amyloid beta-protein (1-42); 0/tau Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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