Document Detail

Adaptive thermogenesis in humans.
MedLine Citation:
PMID:  20935667     Owner:  NLM     Status:  MEDLINE    
The increasing prevalence of obesity and its comorbidities reflects the interaction of genes that favor the storage of excess energy as fat with an environment that provides ad libitum availability of energy-dense foods and encourages an increasingly sedentary lifestyle. Although weight reduction is difficult in and of itself, anyone who has ever lost weight will confirm that it is much harder to keep the weight off once it has been lost. The over 80% recidivism rate to preweight loss levels of body fatness after otherwise successful weight loss is due to the coordinate actions of metabolic, behavioral, neuroendocrine and autonomic responses designed to maintain body energy stores (fat) at a central nervous system-defined 'ideal'. This 'adaptive thermogenesis' creates the ideal situation for weight regain and is operant in both lean and obese individuals attempting to sustain reduced body weights. Much of this opposition to sustained weight loss is mediated by the adipocyte-derived hormone 'leptin'. The multiple systems regulating energy stores and opposing the maintenance of a reduced body weight illustrate that body energy stores in general and obesity in particular are actively 'defended' by interlocking bioenergetic and neurobiological physiologies. Important inferences can be drawn for therapeutic strategies by recognizing obesity as a disease in which the human body actively opposes the 'cure' over long periods of time beyond the initial resolution of symptomatology.
M Rosenbaum; R L Leibel
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of obesity (2005)     Volume:  34 Suppl 1     ISSN:  1476-5497     ISO Abbreviation:  Int J Obes (Lond)     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-11     Completed Date:  2011-03-02     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101256108     Medline TA:  Int J Obes (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  S47-55     Citation Subset:  IM    
Division of Molecular Genetics, Department of Pediatrics, Columbia University, College of Physicians and Surgeons, New York, NY, USA.
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MeSH Terms
Body Weight / physiology*
Energy Intake / physiology*
Energy Metabolism / physiology*
Obesity / complications,  physiopathology*
Thermogenesis / physiology*
Weight Loss
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