Document Detail


Adaptive stress response of glutathione and uric acid metabolism in man following controlled exercise and diet.
MedLine Citation:
PMID:  12193218     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ergometer cycling performance as well as acute exercise-induced changes in the metabolism of energy-intermediates and glutathione (GSH) were investigated in skeletal muscle (SM) of 15 healthy young male subjects (VO(2max) approximately 54.7 mL kg(-1) min(-1), age approximately 25 years), before and after 3 days of controlled 'ìoverload-training' in combination with either high (62% of energy intake) or low (26% of energy intake) dietary intake of carbohydrates. The intake of a carbohydrate-rich diet clearly reduced the depletion of SM glycogen following the short-term training period, paralleled with a positive effect on the endurance performance, but not on high-intensity work-performance. An 'delayed over-reaching effect', defined as impaired work-performance, was observed after 2.5 days of recovery from the short-term training period, irrespective of the carbohydrate content of the diet and basal glycogen level in SM. Taken together, the main and novel findings of present investigation are: (1) an acute decrease of reduced GSH content and altered thiol-redox homeostasis in SM induced by strenuous high-intensity exercise; (2) an adaptive elevation of basal GSH level following the short-term training period; (3) an adaptive decrease of basal GSH level following 2.5 days recovery from training; (4) evidence of a relationship between the SM fibre type, physical performance capacity and GSH turnover during acute bouts of exercise; and (5) no evident effect of the level of carbohydrate intake on metabolism of GSH or energy intermediates. Furthermore, the induction of acute oxidative stress in exercising human SM and the adaptive responses to training are suggested to provide a protective antioxidant phenotype to the exercising SM during periods with repeated intense intermittent training.
Authors:
M B Svensson; B Ekblom; I A Cotgreave; B Norman; B Sjöberg; O Ekblom; B Sjödin; A Sjödin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  176     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-08-23     Completed Date:  2003-01-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  England    
Other Details:
Languages:  eng     Pagination:  43-56     Citation Subset:  IM    
Affiliation:
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological / physiology*
Adenosine Triphosphate / analysis
Adult
Diet*
Erythrocyte Volume / physiology
Exercise / physiology*
Glutathione / analysis,  metabolism*
Glycogen / metabolism
Humans
Inosine Monophosphate / analysis
Lactates / analysis
Male
Muscle, Skeletal / metabolism,  physiology*
Uric Acid / blood,  metabolism*
Chemical
Reg. No./Substance:
0/Lactates; 131-99-7/Inosine Monophosphate; 56-65-5/Adenosine Triphosphate; 69-93-2/Uric Acid; 70-18-8/Glutathione; 9005-79-2/Glycogen

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