Document Detail

Adaptive stress response of glutathione and uric acid metabolism in man following controlled exercise and diet.
MedLine Citation:
PMID:  12193218     Owner:  NLM     Status:  MEDLINE    
Ergometer cycling performance as well as acute exercise-induced changes in the metabolism of energy-intermediates and glutathione (GSH) were investigated in skeletal muscle (SM) of 15 healthy young male subjects (VO(2max) approximately 54.7 mL kg(-1) min(-1), age approximately 25 years), before and after 3 days of controlled 'ìoverload-training' in combination with either high (62% of energy intake) or low (26% of energy intake) dietary intake of carbohydrates. The intake of a carbohydrate-rich diet clearly reduced the depletion of SM glycogen following the short-term training period, paralleled with a positive effect on the endurance performance, but not on high-intensity work-performance. An 'delayed over-reaching effect', defined as impaired work-performance, was observed after 2.5 days of recovery from the short-term training period, irrespective of the carbohydrate content of the diet and basal glycogen level in SM. Taken together, the main and novel findings of present investigation are: (1) an acute decrease of reduced GSH content and altered thiol-redox homeostasis in SM induced by strenuous high-intensity exercise; (2) an adaptive elevation of basal GSH level following the short-term training period; (3) an adaptive decrease of basal GSH level following 2.5 days recovery from training; (4) evidence of a relationship between the SM fibre type, physical performance capacity and GSH turnover during acute bouts of exercise; and (5) no evident effect of the level of carbohydrate intake on metabolism of GSH or energy intermediates. Furthermore, the induction of acute oxidative stress in exercising human SM and the adaptive responses to training are suggested to provide a protective antioxidant phenotype to the exercising SM during periods with repeated intense intermittent training.
M B Svensson; B Ekblom; I A Cotgreave; B Norman; B Sjöberg; O Ekblom; B Sjödin; A Sjödin
Related Documents :
24509998 - Hormonal responses of combining endurance-resistance exercise in healthy young men.
15879168 - Influence of muscle glycogen availability on erk1/2 and akt signaling after resistance ...
16118338 - 17beta-estradiol supplementation decreases glucose rate of appearance and disappearance...
21272338 - Eccentric exercise versus usual-care with older cancer survivors: the impact on muscle ...
6425918 - Effects of body temperature on ventilation, blood gases and acid-base balance in exerci...
20185628 - Exercise training prevents the exaggerated exercise pressor reflex in rats with chronic...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  176     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-08-23     Completed Date:  2003-01-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  England    
Other Details:
Languages:  eng     Pagination:  43-56     Citation Subset:  IM    
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adaptation, Physiological / physiology*
Adenosine Triphosphate / analysis
Erythrocyte Volume / physiology
Exercise / physiology*
Glutathione / analysis,  metabolism*
Glycogen / metabolism
Inosine Monophosphate / analysis
Lactates / analysis
Muscle, Skeletal / metabolism,  physiology*
Uric Acid / blood,  metabolism*
Reg. No./Substance:
0/Lactates; 131-99-7/Inosine Monophosphate; 56-65-5/Adenosine Triphosphate; 69-93-2/Uric Acid; 70-18-8/Glutathione; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Regulation of Ca2+ channel and phosphatase activities by polyamines in intestinal and vascular smoot...
Next Document:  Evidence that action potential generation is not the exclusive determinant to trigger spontaneous my...