| Adaptive rundown of excitatory post-synaptic potentials at synapses between hair cells and eight nerve fibres in the goldfish. | |
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MedLine Citation:
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PMID: 650439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The excitatory post-synaptic potentials (e.p.s.p.s.) evoked by sound stimuli were recorded intracellularly from large afferent eight nerve fibres in the sacculus of the goldfish (S1 fibres). The fish were anaesthetized with MS-222 and spike potentials were suppressed with locally applied tetrodotoxin. 2. The e.p.s.p.s. successively evoked in response to each wound wave showed a marked rundown in size, while no reduction was observed in the microphonic potentials. The amplitude of successive e.p.s.p.s was reduced keeping approximately a fixed ratio to the preceding ones, suggesting that the rundown is attributable to a depletion of transmitter quanta from the release sites. 3. The rate of rundown of successive e.p.s.p.s, however, remained almost unchanged when the intensity of the stimulus sound was changed. It was also observed that, even after the e.p.s.p.s had been completely adapted to a continuous sound, a vigorous discharge of new e.p.s.p.s was observed when the intensity of the sound was increased. 4. These findings seem to indicate that it is the size of the readily available store and not the release fraction that is changed by a change in the sound intensity. 5. The saccular macula was superfused with solutions different in Ca and Mg ion concentrations. High Ca ion concentration brought about an increase in the size of the readily available store as well as the release fraction. 6. Mechanisms underlying these observations were discussed in terms of the quantal release mechanism as well as the morphology of the release sites. |
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Authors:
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T Furukawa; S Matsuura |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of physiology Volume: 276 ISSN: 0022-3751 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 1978 Mar |
Date Detail:
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Created Date: 1978-07-15 Completed Date: 1978-07-15 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 193-209 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation Animals Calcium / pharmacology Cyprinidae / physiology* Evoked Potentials / drug effects Goldfish / physiology* Hair Cells, Auditory / physiology* Magnesium / pharmacology Mechanoreceptors / physiology* Nerve Fibers / physiology Neurons, Afferent / physiology Saccule and Utricle / physiology Synapses / physiology* Vestibulocochlear Nerve / physiology* |
| Chemical | |
Reg. No./Substance:
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7439-95-4/Magnesium; 7440-70-2/Calcium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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