Document Detail


Adaptive responses of rats to prolonged treatment with epinephrine.
MedLine Citation:
PMID:  6454352     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rats were given a daily injection of L-epinephrine, 100 micrograms/100 g body wt, for 6 wk. The hearts of the epinephrine-treated animals were heavier (11.5%), and blood glucose and plasma insulin concentrations were lower than those of control rats. Acute responses to epinephrine were compared in the two groups. An increase in blood glucose and decreases in plasma insulin, liver glycogen, and muscle glycogen occurred in both groups. The magnitude of these responses were similar in the two groups except for the decrease in muscle glycogen, which was smaller in the chronic epinephrine-treatment group. There were no changes in respiratory capacity, citrate synthase or succinate dehydrogenase activities, or in cytochrome c concentration in skeletal muscle in response to 6 wk of epinephrine treatment. These results are compatible with the suggestion that catecholamines may play a role in some of the metabolic and cardiac adaptations to exercise training. However, they argue strongly against the hypothesis that catecholamines are responsible for inducing the increase in muscle mitochondria that occurs in response to exercise training.
Authors:
R D Fell; S E Terblanche; W W Winder; J O Holloszy
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  241     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1981 Jul 
Date Detail:
Created Date:  1981-08-27     Completed Date:  1981-08-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  C55-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Glucose / metabolism*
Cardiomegaly / chemically induced
Epinephrine / blood,  pharmacology*
Glycogen / metabolism
Heart / drug effects,  physiology*
Insulin / blood*
Lactates / blood
Liver Glycogen / metabolism
Male
Mitochondria, Muscle / drug effects,  metabolism
Muscles / metabolism
Rats
Grant Support
ID/Acronym/Agency:
AG-00425/AG/NIA NIH HHS; AM-07226/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Lactates; 0/Liver Glycogen; 11061-68-0/Insulin; 51-43-4/Epinephrine; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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