Document Detail

Adaptive responses of the embryo to maternal diet and consequences for post-implantation development.
MedLine Citation:
PMID:  22394716     Owner:  NLM     Status:  MEDLINE    
Maternal periconceptional (PC) nutrition, coupled with maternal physiological condition, can impact on reproductive performance and potential across mammalian species. Oocyte quality and embryo development are affected adversely by either nutrient restriction or excess. Moreover, the quality of maternal PC nutrition can have lasting effects through fetal development and postnatally into adulthood. Chronic disease, notably cardiovascular and metabolic disease, and abnormal behaviour have been identified in adult offspring in small and large animal models of PC nutrient restriction. These long-term effects associate with compensatory responses that begin from the time of early embryo development. This review assesses the field of PC nutrition in vivo on short- and long-term developmental consequences in rodent and ruminant models and considers the implications for human health.
Tom P Fleming; Emma S Lucas; Adam J Watkins; Judith J Eckert
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Reproduction, fertility, and development     Volume:  24     ISSN:  1031-3613     ISO Abbreviation:  Reprod. Fertil. Dev.     Publication Date:  2011  
Date Detail:
Created Date:  2012-03-07     Completed Date:  2012-08-14     Revised Date:  2014-07-22    
Medline Journal Info:
Nlm Unique ID:  8907465     Medline TA:  Reprod Fertil Dev     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  35-44     Citation Subset:  IM    
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MeSH Terms
Adaptation, Physiological / physiology*
Embryo, Mammalian / physiology*
Embryonic Development / physiology*
Fertility / physiology
Maternal Nutritional Physiological Phenomena / physiology*
Maternal-Fetal Exchange / physiology
Models, Animal
Grant Support
BB/I001840/1//Biotechnology and Biological Sciences Research Council; G0100558//Medical Research Council; //Biotechnology and Biological Sciences Research Council; //Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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