Document Detail

Adaptive response to low doses of gamma-ray in Chinese hamster cells: determined by cell survival and DNA synthesis.
MedLine Citation:
PMID:  7820118     Owner:  NLM     Status:  MEDLINE    
This study was undertaken to examine the adaptive response in Chinese hamster V79 cells using the cell survival (colony formation assay) and DNA synthesis ([3H]thymidine incorporation) as endpoints. When V79 cells were preirradiated with an adapting dose (0.05 Gy), their survival after irradiation with the challenging dose (4 Gy) was about 120% of the control without such preirradiation. Following irradiation with the challenging dose, the DNA synthesis of the preirradiated cells was less reduced than those without it. The adaptive responses were considered to be associated with the signal transduction via protein kinase C from the results that this response was not observed when the cells were preirradiated with the adapting dose in the presence of protein kinase C inhibitor, H-7.
Y Ibuki; R Goto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  17     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1995-02-10     Completed Date:  1995-02-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1111-3     Citation Subset:  IM    
Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Japan.
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MeSH Terms
Adaptation, Physiological / radiation effects*
CHO Cells
Cell Survival / radiation effects
Colony-Forming Units Assay
DNA / biosynthesis*,  radiation effects
Gamma Rays*
Isoquinolines / pharmacology
Piperazines / pharmacology
Protein Kinase C / antagonists & inhibitors,  physiology
Signal Transduction / radiation effects
Thymidine / metabolism
Reg. No./Substance:
0/Isoquinolines; 0/Piperazines; 50-89-5/Thymidine; 84477-87-2/1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 9007-49-2/DNA; EC Kinase C

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