| Adaptive regulation of lipoprotein lipase and salt-resistant lipase activities in essential fatty acid deficiency: an experimental study in the rat. | |
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MedLine Citation:
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PMID: 2246972 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lipoprotein lipase (LPL) activities of postheparin plasma, heart, lungs, and adipose tissue, and salt-resistant lipase (hepatic lipase, SRL) activities of postheparin plasma, liver, and adrenals were examined in essential fatty acid deficient (EFAD) rats and in age-matched controls. The LPL activity of heart was higher in the deficient than in the control rats, but did not differ in the other tissues. The SRL activity of postheparin plasma was twofold higher, and that of liver and adrenals approximately 50% higher in the group with EFA deficiency. It is suggested that SRL exhibits an adaptive up-regulation in EFA deficiency. This up-regulation may be linked to a role for the enzyme in the transport of polyenoic fatty acids. |
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Authors:
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A Nilsson; L Hjelte; P Nilsson-Ehle; B Strandvik |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 39 ISSN: 0026-0495 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 1990 Dec |
Date Detail:
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Created Date: 1991-01-08 Completed Date: 1991-01-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1305-8 Citation Subset: IM |
Affiliation:
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Department of Medicine, University Hospital of Lund, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological* Adrenal Glands / enzymology Animals Drug Resistance Fatty Acids, Essential / deficiency* Heparin / pharmacology Lipase / blood, metabolism* Lipoprotein Lipase / metabolism* Liver / enzymology Male Rats Rats, Inbred Strains Sodium Chloride / pharmacology* Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Essential; 7647-14-5/Sodium Chloride; 9005-49-6/Heparin; EC 3.1.1.3/Lipase; EC 3.1.1.34/Lipoprotein Lipase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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