Document Detail


Adaptive regulation of lipoprotein lipase and salt-resistant lipase activities in essential fatty acid deficiency: an experimental study in the rat.
MedLine Citation:
PMID:  2246972     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lipoprotein lipase (LPL) activities of postheparin plasma, heart, lungs, and adipose tissue, and salt-resistant lipase (hepatic lipase, SRL) activities of postheparin plasma, liver, and adrenals were examined in essential fatty acid deficient (EFAD) rats and in age-matched controls. The LPL activity of heart was higher in the deficient than in the control rats, but did not differ in the other tissues. The SRL activity of postheparin plasma was twofold higher, and that of liver and adrenals approximately 50% higher in the group with EFA deficiency. It is suggested that SRL exhibits an adaptive up-regulation in EFA deficiency. This up-regulation may be linked to a role for the enzyme in the transport of polyenoic fatty acids.
Authors:
A Nilsson; L Hjelte; P Nilsson-Ehle; B Strandvik
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  39     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-01-08     Completed Date:  1991-01-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1305-8     Citation Subset:  IM    
Affiliation:
Department of Medicine, University Hospital of Lund, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological*
Adrenal Glands / enzymology
Animals
Drug Resistance
Fatty Acids, Essential / deficiency*
Heparin / pharmacology
Lipase / blood,  metabolism*
Lipoprotein Lipase / metabolism*
Liver / enzymology
Male
Rats
Rats, Inbred Strains
Sodium Chloride / pharmacology*
Tissue Distribution
Chemical
Reg. No./Substance:
0/Fatty Acids, Essential; 7647-14-5/Sodium Chloride; 9005-49-6/Heparin; EC 3.1.1.3/Lipase; EC 3.1.1.34/Lipoprotein Lipase

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