Document Detail

Adaptive phylogeography: functional divergence between haemoglobins derived from different glacial refugia in the bank vole.
MedLine Citation:
PMID:  24827438     Owner:  NLM     Status:  In-Data-Review    
Over the years, researchers have used presumptively neutral molecular variation to infer the origins of current species' distributions in northern latitudes (especially Europe). However, several reported examples of genic and chromosomal replacements suggest that end-glacial colonizations of particular northern areas may have involved genetic input from different source populations at different times, coupled with competition and selection. We investigate the functional consequences of differences between two bank vole (Clethrionomys glareolus) haemoglobins deriving from different glacial refugia, one of which partially replaced the other in Britain during end-glacial climate warming. This allows us to examine their adaptive divergence and hence a possible role of selection in the replacement. We determine the amino acid substitution Ser52Cys in the major expressed β-globin gene as the allelic difference. We use structural modelling to reveal that the protein environment renders the 52Cys thiol a highly reactive functional group and we show its reactivity in vitro. We demonstrate that possessing the reactive thiol in haemoglobin increases the resistance of bank vole erythrocytes to oxidative stress. Our study thus provides striking evidence for physiological differences between products of genic variants that spread at the expense of one another during colonization of an area from different glacial refugia.
Petr Kotlík; Silvia Marková; Libor Vojtek; Antonín Stratil; Vlastimil Slechta; Pavel Hyršl; Jeremy B Searle
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings. Biological sciences / The Royal Society     Volume:  281     ISSN:  1471-2954     ISO Abbreviation:  Proc. Biol. Sci.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-05-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101245157     Medline TA:  Proc Biol Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
Copyright Information:
© 2014 The Author(s) Published by the Royal Society. All rights reserved.
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