| Adaptive immunity in atherogenesis: new insights and therapeutic approaches. | |
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MedLine Citation:
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PMID: 23281407 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many remarkable advances have improved our understanding of the cellular and molecular events in the pathogenesis of atherosclerosis. Chief among these is the accumulating knowledge of how the immune system contributes to all phases of atherogenesis, including well-known inflammatory reactions consequent to intimal trapping and oxidation of LDL. Advances in our understanding of the innate and adaptive responses to these events have helped to clarify the role of inflammation in atherogenesis and suggested new diagnostic modalities and novel therapeutic targets. Here we focus on recent advances in understanding how adaptive immunity affects atherogenesis. |
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Authors:
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Andrew H Lichtman; Christoph J Binder; Sotirios Tsimikas; Joseph L Witztum |
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Publication Detail:
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Type: Journal Article; Review Date: 2013-01-02 |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 123 ISSN: 1558-8238 ISO Abbreviation: J. Clin. Invest. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-02 Completed Date: 2013-03-11 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
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Languages: eng Pagination: 27-36 Citation Subset: AIM; IM |
Affiliation:
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Vascular Research Division, Department of Pathology, Brigham and Women’s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA. alichtman@rics.bwh.harvard.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptive Immunity* Animals Atherosclerosis* / diagnosis, immunology, pathology, physiopathology, therapy Humans Inflammation / diagnosis, immunology, pathology, physiopathology, therapy Lipoproteins, LDL / immunology* Oxidation-Reduction |
| Chemical | |
Reg. No./Substance:
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0/Lipoproteins, LDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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