Document Detail


Adaptive immunity in atherogenesis: new insights and therapeutic approaches.
MedLine Citation:
PMID:  23281407     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Many remarkable advances have improved our understanding of the cellular and molecular events in the pathogenesis of atherosclerosis. Chief among these is the accumulating knowledge of how the immune system contributes to all phases of atherogenesis, including well-known inflammatory reactions consequent to intimal trapping and oxidation of LDL. Advances in our understanding of the innate and adaptive responses to these events have helped to clarify the role of inflammation in atherogenesis and suggested new diagnostic modalities and novel therapeutic targets. Here we focus on recent advances in understanding how adaptive immunity affects atherogenesis.
Authors:
Andrew H Lichtman; Christoph J Binder; Sotirios Tsimikas; Joseph L Witztum
Related Documents :
23985377 - Thymic stromal lymphopoietin attenuates the development of atherosclerosis in apoe-/- m...
14646547 - Evidence for an interleukin-1beta converting enzyme (ice)-like activity distinct from i...
24904537 - A new paradigm: innate immune sensing of viruses via the unfolded protein response.
24838617 - Oxygen glucose deprivation/reperfusion astrocytes promotes primary neural stem/progenit...
17587197 - Immune modulation of hla-g dimer in maternal-fetal interface.
19539777 - The e2f family and the role of e2f1 in apoptosis.
Publication Detail:
Type:  Journal Article; Review     Date:  2013-01-02
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  123     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-03-11     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  27-36     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adaptive Immunity*
Animals
Atherosclerosis* / diagnosis,  immunology,  pathology,  physiopathology,  therapy
Humans
Inflammation / diagnosis,  immunology,  pathology,  physiopathology,  therapy
Lipoproteins, LDL / immunology*
Oxidation-Reduction
Grant Support
ID/Acronym/Agency:
R01 HL087282/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Lipoproteins, LDL
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Genetic mutations and mechanisms in dilated cardiomyopathy.
Next Document:  Signaling effectors underlying pathologic growth and remodeling of the heart.