Document Detail

Adaptive immunity in atherogenesis: new insights and therapeutic approaches.
MedLine Citation:
PMID:  23281407     Owner:  NLM     Status:  MEDLINE    
Many remarkable advances have improved our understanding of the cellular and molecular events in the pathogenesis of atherosclerosis. Chief among these is the accumulating knowledge of how the immune system contributes to all phases of atherogenesis, including well-known inflammatory reactions consequent to intimal trapping and oxidation of LDL. Advances in our understanding of the innate and adaptive responses to these events have helped to clarify the role of inflammation in atherogenesis and suggested new diagnostic modalities and novel therapeutic targets. Here we focus on recent advances in understanding how adaptive immunity affects atherogenesis.
Andrew H Lichtman; Christoph J Binder; Sotirios Tsimikas; Joseph L Witztum
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Publication Detail:
Type:  Journal Article; Review     Date:  2013-01-02
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  123     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-03-11     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  27-36     Citation Subset:  AIM; IM    
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MeSH Terms
Adaptive Immunity*
Atherosclerosis* / diagnosis,  immunology,  pathology,  physiopathology,  therapy
Inflammation / diagnosis,  immunology,  pathology,  physiopathology,  therapy
Lipoproteins, LDL / immunology*
Grant Support
Reg. No./Substance:
0/Lipoproteins, LDL

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