| Adaptive evolution: evaluating empirical support for theoretical predictions. | |
| | |
MedLine Citation:
|
PMID: 23154809 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Adaptive evolution is shaped by the interaction of population genetics, natural selection and underlying network and biochemical constraints. Variation created by mutation, the raw material for evolutionary change, is translated into phenotypes by flux through metabolic pathways and by the topography and dynamics of molecular networks. Finally, the retention of genetic variation and the efficacy of selection depend on population genetics and demographic history. Emergent high-throughput experimental methods and sequencing technologies allow us to gather more evidence and to move beyond the theory in different systems and populations. Here we review the extent to which recent evidence supports long-established theoretical principles of adaptation. |
| | |
Authors:
|
Carrie F Olson-Manning; Maggie R Wagner; Thomas Mitchell-Olds |
Related Documents
:
|
23110899 - Mutation of arabidopsis spliceosomal timekeeper locus1 causes circadian clock defects. 7698759 - A homozygous nonsense mutation in the beta 3 chain gene of laminin 5 (lamb3) in herlitz... 9713229 - Linear epidermolytic epidermal naevus--a case report. 14564079 - Collagens, the basic proteins of the human body. 10615129 - Mutations in atp2c1, encoding a calcium pump, cause hailey-hailey disease. 21995399 - Vemurafenib in melanoma with braf v600e mutation. 15274399 - Alterations of the k-ras and p53 genes and microsatellite instability in sporadic color... 11404339 - Interchromosomal gene conversion at an endogenous human cell locus. 21609749 - Role of functional dopaminergic gene polymorphisms in the etiology of idiopathic intell... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Nature reviews. Genetics Volume: 13 ISSN: 1471-0064 ISO Abbreviation: Nat. Rev. Genet. Publication Date: 2012 Dec |
Date Detail:
|
Created Date: 2012-11-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100962779 Medline TA: Nat Rev Genet Country: England |
Other Details:
|
Languages: eng Pagination: 867-77 Citation Subset: IM |
Affiliation:
|
Department of Biology, BOX 90338, Program in Genetics and Genomics, Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina 27708, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evolution of genetic and genomic features unique to the human lineage.
Next Document: Human mitochondrial DNA: roles of inherited and somatic mutations.