Document Detail


Adaptive evolution: evaluating empirical support for theoretical predictions.
MedLine Citation:
PMID:  23154809     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adaptive evolution is shaped by the interaction of population genetics, natural selection and underlying network and biochemical constraints. Variation created by mutation, the raw material for evolutionary change, is translated into phenotypes by flux through metabolic pathways and by the topography and dynamics of molecular networks. Finally, the retention of genetic variation and the efficacy of selection depend on population genetics and demographic history. Emergent high-throughput experimental methods and sequencing technologies allow us to gather more evidence and to move beyond the theory in different systems and populations. Here we review the extent to which recent evidence supports long-established theoretical principles of adaptation.
Authors:
Carrie F Olson-Manning; Maggie R Wagner; Thomas Mitchell-Olds
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Nature reviews. Genetics     Volume:  13     ISSN:  1471-0064     ISO Abbreviation:  Nat. Rev. Genet.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-16     Completed Date:  2013-01-17     Revised Date:  2013-08-27    
Medline Journal Info:
Nlm Unique ID:  100962779     Medline TA:  Nat Rev Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  867-77     Citation Subset:  IM    
Affiliation:
Department of Biology, BOX 90338, Program in Genetics and Genomics, Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina 27708, USA.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Biological / genetics*
Alleles
Animals
Epistasis, Genetic
Evolution, Molecular*
Gene Flow
Gene Regulatory Networks
Genetics, Population
Humans
Models, Genetic*
Mutation
Recombination, Genetic
Selection, Genetic
Grant Support
ID/Acronym/Agency:
5T32GM007754‑32/GM/NIGMS NIH HHS; R01 GM086496/GM/NIGMS NIH HHS; R01 GM086496/GM/NIGMS NIH HHS
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