Document Detail

Adaptive changes of mesenteric arteries in pregnancy: a meta-analysis.
MedLine Citation:
PMID:  22821990     Owner:  NLM     Status:  Publisher    
The vascular response to pregnancy has been frequently studied in mesenteric artery models, by investigating endothelial cell (EC) and smooth muscle cell (SMC) dependent responses to mechanical (flow-mediated vasodilation, myogenic reactivity, and vascular compliance) and pharmacological stimuli (G-protein coupled receptor responses: Gq(EC), Gs(SMC), Gq(SMC)). It is unclear to what extent these pathways contribute to normal pregnancy-induced vasodilatation across species, strains, and/or gestational age, and at which receptor level pregnancy affects the pathways. We performed a meta-analysis on responses to mechanical and pharmacological stimuli associated with pregnancy-induced vasodilation of mesenteric arteries and included 55 (188 responses) out of 398 studies. Most included studies (84%) were performed in Wistar rats (WR) and Sprague Dawley (SDR), and compared late gestation versus non-pregnant controls (80%). Pregnancy promotes flow-mediated vasodilation in all investigated species. Only in SDR, pregnancy additionally stimulates both vasodilator GqEC sensitivity (EC(50) reduced by -0.76 [-0.92, - 0.60] log[M]) and Gs(SMC) sensitivity (EC(50) reduced by -0.51 [-0.82, -0.20] log[M]), depresses vasopressor Gq(SMC) sensitivity (EC(50) increase in SDR by 0.23 [0.16, 0.31] log[M]) and enhances arterial compliance. We conclude that 1) Pregnancy facilitates flow-mediated vasodilation at term, amongst all investigated species; the contribution of additional vascular responses is species and strain specific, 2) Late pregnancy mediates vasodilation through changes at the receptor level, for the substances tested. The initial steps of vasodilation in early pregnancy remain to be elucidated.
Joris van Drongelen; Carlijn R Hooijmans; Frederik K Lotgering; Paul Smits; Marc Ea Spaanderman
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-20
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  -     ISSN:  1522-1539     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Radboud University Nijmegen Medical Centre.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  TNF-? impairs endothelial function in adipose tissue resistance arteries of mice with diet-induced o...
Next Document:  Non-viral gene therapy targeting cardiovascular system.