Document Detail

Adaptive changes in the rat dopaminergic transmission following repeated lithium administration.
MedLine Citation:
PMID:  8872863     Owner:  NLM     Status:  MEDLINE    
In the present study the alterations in the contents of dopamine (DA) and metabolites, as well as in the levels of mRNA coding for DA receptor D2, were determined in the rat striatum (STR) and nucleus accumbens septi (NAS), in correlation with the duration of lithium administration. Single or subchronic (3 days) administration of lithium produced less consistent effects as far as the levels of DA and metabolites are concerned; however, following 7 or 14 days of lithium administration, the DA release from terminals was significantly attenuated and the effect was more pronounced in NAS. After the same time of treatment, the increase in the levels of mRNA coding for the D2 receptor was increased; this might be interpreted as an adaptive change to the decreased dopaminergic transmission following the prolonged administration of lithium.
M Dziedzicka-Wasylewska; M Maćkowiak; K Fijat; K Wedzony
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neural transmission (Vienna, Austria : 1996)     Volume:  103     ISSN:  0300-9564     ISO Abbreviation:  J Neural Transm     Publication Date:  1996  
Date Detail:
Created Date:  1997-01-15     Completed Date:  1997-01-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9702341     Medline TA:  J Neural Transm     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  765-76     Citation Subset:  IM    
Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
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MeSH Terms
3,4-Dihydroxyphenylacetic Acid / metabolism
Adaptation, Physiological / drug effects*
Analysis of Variance
Corpus Striatum / drug effects*,  metabolism
Dopamine / metabolism,  physiology*
Drug Administration Schedule
Homovanillic Acid / metabolism
In Situ Hybridization
Lithium Chloride / pharmacology*
Nucleus Accumbens / drug effects*,  metabolism
RNA, Messenger / metabolism
Rats, Wistar
Receptors, Dopamine D2 / genetics
Synaptic Transmission / drug effects*
Reg. No./Substance:
0/RNA, Messenger; 0/Receptors, Dopamine D2; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 7447-41-8/Lithium Chloride

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