| Adaptive changes in the rat dopaminergic transmission following repeated lithium administration. | |
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MedLine Citation:
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PMID: 8872863 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the present study the alterations in the contents of dopamine (DA) and metabolites, as well as in the levels of mRNA coding for DA receptor D2, were determined in the rat striatum (STR) and nucleus accumbens septi (NAS), in correlation with the duration of lithium administration. Single or subchronic (3 days) administration of lithium produced less consistent effects as far as the levels of DA and metabolites are concerned; however, following 7 or 14 days of lithium administration, the DA release from terminals was significantly attenuated and the effect was more pronounced in NAS. After the same time of treatment, the increase in the levels of mRNA coding for the D2 receptor was increased; this might be interpreted as an adaptive change to the decreased dopaminergic transmission following the prolonged administration of lithium. |
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Authors:
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M Dziedzicka-Wasylewska; M Maćkowiak; K Fijat; K Wedzony |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neural transmission (Vienna, Austria : 1996) Volume: 103 ISSN: 0300-9564 ISO Abbreviation: J Neural Transm Publication Date: 1996 |
Date Detail:
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Created Date: 1997-01-15 Completed Date: 1997-01-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9702341 Medline TA: J Neural Transm Country: AUSTRIA |
Other Details:
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Languages: eng Pagination: 765-76 Citation Subset: IM |
Affiliation:
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Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3,4-Dihydroxyphenylacetic Acid
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metabolism Adaptation, Physiological / drug effects* Analysis of Variance Animals Corpus Striatum / drug effects*, metabolism Dopamine / metabolism, physiology* Drug Administration Schedule Homovanillic Acid / metabolism In Situ Hybridization Lithium Chloride / pharmacology* Male Nucleus Accumbens / drug effects*, metabolism RNA, Messenger / metabolism Rats Rats, Wistar Receptors, Dopamine D2 / genetics Synaptic Transmission / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; 0/Receptors, Dopamine D2; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 7447-41-8/Lithium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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