Document Detail

Adaptive changes in firing rates in goldfish auditory fibers as related to changes in mean amplitude of excitatory postsynaptic potentials.
MedLine Citation:
PMID:  6311994     Owner:  NLM     Status:  MEDLINE    
Relationship between the firing rate in the auditory fibers and the amplitude of the excitatory postsynaptic potentials (EPSPs) that trigger afferent impulses was investigated. The unitary EPSPs and spike potentials were extracellularly recorded from the goldfish large auditory fibers by means of a microelectrode placed close to the distal terminals. The relation between the firing rate and the amplitude of the EPSPs was studied using a variety of stimulus conditions. The firing probability of phase-locked impulses was linearly related to the mean amplitude of the EPSPs determined for the same time bins. The same linear relation was applicable for the firings elicited by different intensities of sound and observed at various times after onset and also for the firings produced by applying step increments in intensity. The threshold amplitude of the EPSPs required for initiation of afferent impulses was unchanged in these different situations. Random changes in the amplitude of successively evoked EPSPs were found to underlie the probabilistic nature of the sequence of afferent firings. The present results indicate that the per stimulus adaptation and incremental and decremental responses, as observed in the firing probability of afferent impulses, are largely attributable to adaptive changes in the mean amplitude of the evoked EPSPs and not to changes in excitability of the auditory fibers.
M Kuno
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurophysiology     Volume:  50     ISSN:  0022-3077     ISO Abbreviation:  J. Neurophysiol.     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375404     Medline TA:  J Neurophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  573-81     Citation Subset:  IM    
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MeSH Terms
Adaptation, Physiological
Auditory Perception / physiology*
Cyprinidae / physiology*
Evoked Potentials, Auditory
Goldfish / physiology*
Loudness Perception / physiology
Synapses / physiology
Synaptic Transmission
Vestibulocochlear Nerve / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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