Document Detail


Adaptive immunity in ankylosing spondylitis: phenotype and functional alterations of T-cells before and during infliximab therapy.
MedLine Citation:
PMID:  21969839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our aim was to assess the phenotype of T-cell subsets in patients with ankylosing spondylitis (AS), a chronic inflammatory rheumatic disease. In addition, we also tested short-term T-cell activation characteristics. Measurements were done in 13 AS patients before and during the intravenous therapy with anti-TNF agent infliximab (IFX). Flow cytometry was used to determine T-cell subsets in peripheral blood and their intracellular signaling during activation. The prevalence of Th2 and Th17 cells responsible for the regulation of adaptive immunity was higher in AS than in 9 healthy controls. Although IFX therapy improved patients' condition, immune phenotype did not normalize. Cytoplasmic and mitochondrial calcium responses of CD4+ and CD8+ cells to a specific activation were delayed, while NO generation was increased in AS. NO generation normalized sooner upon IFX than calcium response. These results suggest an abnormal immune phenotype with functional disturbances of CD4+ and CD8+ cells in AS.
Authors:
Balázs Szalay; Gergo Mészáros; Áron Cseh; Lilla Ács; Magdolna Deák; László Kovács; Barna Vásárhelyi; Attila Balog
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-09-28
Journal Detail:
Title:  Clinical & developmental immunology     Volume:  2012     ISSN:  1740-2530     ISO Abbreviation:  Clin. Dev. Immunol.     Publication Date:  2012  
Date Detail:
Created Date:  2011-10-04     Completed Date:  2012-01-18     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  101183692     Medline TA:  Clin Dev Immunol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  808724     Citation Subset:  IM    
Affiliation:
First Department of Pediatrics, Semmelweis University, Bókay János Utca 53-54, 1083 Budapest, Hungary. szalay.b@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adaptive Immunity
Adult
Antibodies, Monoclonal / administration & dosage,  therapeutic use*
CD4-Positive T-Lymphocytes / immunology
CD8-Positive T-Lymphocytes / immunology
Female
Flow Cytometry
Humans
Lymphocyte Activation
Male
Middle Aged
Phenotype
Spondylitis, Ankylosing / immunology*,  therapy*
T-Lymphocyte Subsets / immunology*
T-Lymphocytes / immunology
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/infliximab
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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