Document Detail

Adaptive Changes in Mycobacterium avium Gene Expression Profile Following Infection of Genetically Susceptible and Resistant Mice.
MedLine Citation:
PMID:  22649654     Owner:  NLM     Status:  PubMed-not-MEDLINE    
We performed a comparative analysis ofMycobacterium aviumtranscriptomes (strain 724R) in infected mice of two different strains- resistant and susceptible to infection. Sets of mycobacterial genes transcribed in lung tissue were defined, and differentially transcribed genes were revealed. Our results indicate thatM. aviumgenes coding for enzymes of the Krebs cycle, oxidative phosphorylation, NO reduction, fatty acid biosynthesis, replication, translation, and genome modification are expressed at high levels in the lungs of genetically susceptible mice. The expression of genes responsible for cell wall properties, anaerobic nitrate respiration, fatty acid degradation, synthesis of polycyclic fatty acid derivatives, and biosynthesis of mycobactin and other polyketides is increased in the resistant mice. In the resistant host environment,Mycobacterium aviumapparently transitions to a latent state caused by the deficiency in divalent cations and characterised by anaerobic respiration, degradation of fatty acids, and modification of cell wall properties.
D V Ignatov; T A Skvortsov; K B Majorov; A S Apt; T L Azhikina
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta naturae     Volume:  2     ISSN:  2075-8251     ISO Abbreviation:  Acta Naturae     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2012-05-31     Completed Date:  2012-08-23     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101525823     Medline TA:  Acta Naturae     Country:  Russia (Federation)    
Other Details:
Languages:  eng     Pagination:  78-83     Citation Subset:  -    
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences.
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