| Adapter and enzymatic functions of proteases in T-cell activation. | |
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MedLine Citation:
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PMID: 19909374 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Proteases control many vital aspects of humoral and cellular immune responses, including the maturation of cytokines and the killing of target cells. Recently, it has become evident that triggering of the T-cell receptor controls T-cell proliferation through proteases such as mucosa-associated lymphoid tissue 1 (MALT1) and Caspase-8 that act both as adapters and enzymes. Here, we discuss the role of these and other proteases that are relevant to the control of the T-cell response and represent interesting targets of therapeutic immunomodulation. |
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Authors:
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Stephan Hailfinger; Fabien Rebeaud; Margot Thome |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Immunological reviews Volume: 232 ISSN: 1600-065X ISO Abbreviation: Immunol. Rev. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7702118 Medline TA: Immunol Rev Country: Denmark |
Other Details:
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Languages: eng Pagination: 334-47 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, University of Lausanne, Epalinges, Switzerland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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