Document Detail

Adaptations or pathologies? Long-term changes in brain and behavior after a single exposure to severe threat.
MedLine Citation:
PMID:  15036929     Owner:  NLM     Status:  MEDLINE    
The experience of a single threatening situation may alter the behavior of an animal in a long-lasting way. Long-lasting changes in behavior have been induced in laboratory animals to model and investigate the development and neural substrate of human psychopathologies. Under natural conditions, however, changes in behavior after an aversive experience may be adaptive because behavioral modifications allow animals to adjust to a threat for extended periods of time. In the laboratory setting, properties of the aversive situation and the potential of the animal to respond to the threat may be altered and lead to extensive, prolonged changes, indicating a failure in behavioral regulation. Such long-term changes seem to be mediated by neuronal alterations in components of the fear pathway. To understand psychopathologies, determinants of exaggerated responsivity and the underlying molecular and neural processes have to be analyzed in a comparative way under conditions that produce normal and abnormal fear and anxiety.
Christoph P Wiedenmayer
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Neuroscience and biobehavioral reviews     Volume:  28     ISSN:  0149-7634     ISO Abbreviation:  Neurosci Biobehav Rev     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-23     Completed Date:  2004-05-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7806090     Medline TA:  Neurosci Biobehav Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-12     Citation Subset:  IM    
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
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MeSH Terms
Adaptation, Psychological / physiology*
Association Learning / physiology*
Avoidance Learning / physiology*
Behavior, Animal / physiology*
Brain / physiology*
Escape Reaction / physiology
Neuronal Plasticity
Grant Support

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