Document Detail


Adaptations against heme toxicity in blood-feeding arthropods.
MedLine Citation:
PMID:  16551546     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A blood-sucking habit appeared independently several times in the course of arthropod evolution. However, from more than a million species of insects and arachnids presently living on earth, only about 14,000 species developed the capacity to feed on vertebrate blood. This figure suggests the existence of severe physiological constraints for the evolution of hematophagy, implying the selective advantage of special adaptations related to the use of blood as a food source. Digestion of vertebrate hemoglobin in the midgut of blood-feeding arthropods results in the production of large amounts of heme, a potentially cytotoxic molecule. Here we will review mechanisms by which heme can exert biological damage, together with a wide spectrum of adaptations developed by blood-feeding insects and ticks to counteract its deleterious effects. In spite of the existence of a great molecular diversity of protective mechanisms, different hematophagous organisms developed convergent solutions that may be physiologically equivalent.
Authors:
Aurélio V Graça-Souza; Clarissa Maya-Monteiro; Gabriela O Paiva-Silva; Glória R C Braz; Márcia C Paes; Marcos H F Sorgine; Marcus F Oliveira; Pedro L Oliveira
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2006-01-19
Journal Detail:
Title:  Insect biochemistry and molecular biology     Volume:  36     ISSN:  0965-1748     ISO Abbreviation:  Insect Biochem. Mol. Biol.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-22     Completed Date:  2006-06-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9207282     Medline TA:  Insect Biochem Mol Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  322-35     Citation Subset:  IM    
Affiliation:
Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, Centro de Ciencias da Saude, Av. Brigadeiro Trompowsky, s/n, Cidade Universitária, Ilha do Fundão, 21941-690 Rio de Janeiro, RJ, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological*
Animals
Antioxidants / physiology
Arthropods / parasitology,  physiology*
Feeding Behavior
Heme / metabolism*
Hemeproteins / physiology
Lipid Peroxidation
Oxidative Stress
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Hemeproteins; 14875-96-8/Heme

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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