Document Detail


Adaptations of mouse skeletal muscle to low-intensity vibration training.
MedLine Citation:
PMID:  23274599     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: We tested the hypothesis that low-intensity vibration training in mice improves contractile function of hindlimb skeletal muscles and promotes exercise-related cellular adaptations.
METHODS: We subjected C57BL/6J mice to 6 wk, 5 d·wk, 15 min·d of sham or low-intensity vibration (45 Hz, 1.0g) while housed in traditional cages (Sham-Active, n = 8; Vibrated-Active, n = 10) or in small cages to restrict physical activity (Sham-Restricted, n = 8; Vibrated-Restricted, n = 8). Contractile function and resistance to fatigue were tested in vivo (anterior and posterior crural muscles) and ex vivo on the soleus muscle. Tibialis anterior and soleus muscles were evaluated histologically for alterations in oxidative metabolism, capillarity, and fiber types. Epididymal fat pad and hindlimb muscle masses were measured. Two-way ANOVAs were used to determine the effects of vibration and physical inactivity.
RESULTS: Vibration training resulted in a 10% increase in maximal isometric torque (P = 0.038) and 16% faster maximal rate of relaxation (P = 0.030) of the anterior crural muscles. Posterior crural muscles were unaffected by vibration, except greater rates of contraction in Vibrated-Restricted mice compared with Vibrated-Active and Sham-Restricted mice (P = 0.022). Soleus muscle maximal isometric tetanic force tended to be greater (P = 0.057), and maximal relaxation was 20% faster (P = 0.005) in vibrated compared with sham mice. The restriction of physical activity induced muscle weakness but was not required for vibration to be effective in improving strength or relaxation. Vibration training did not affect muscle fatigability or any indicator of cellular adaptation investigated (P ≥ 0.431). Fat pad but not hindlimb muscle masses were affected by vibration training.
CONCLUSION: Vibration training in mice improved muscle contractility, specifically strength and relaxation rates, with no indication of adverse effects to muscle function or cellular adaptations.
Authors:
James N McKeehen; Susan A Novotny; Kristen A Baltgalvis; Jarrod A Call; David J Nuckley; Dawn A Lowe
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  45     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-20     Completed Date:  2014-02-03     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1051-9     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological*
Animals
Biological Markers / metabolism
Male
Mice
Mice, Inbred C57BL
Motor Activity
Muscle Contraction / physiology*
Muscle Fatigue / physiology
Muscle Strength / physiology*
Muscle, Skeletal / anatomy & histology,  metabolism,  physiology*
Physical Conditioning, Animal / instrumentation,  methods*
Random Allocation
Vibration*
Grant Support
ID/Acronym/Agency:
K02 AG036827/AG/NIA NIH HHS; K02-AG036827/AG/NIA NIH HHS; P30-AR0507220/AR/NIAMS NIH HHS; T32 AR007612/AR/NIAMS NIH HHS; T32-AR07612/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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