Document Detail


Adaptation of vasomotor function of human coronary arterioles to the simultaneous presence of obesity and hypertension.
MedLine Citation:
PMID:  17823369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: We hypothesized that simultaneous presence of obesity and hypertension activates adaptive vascular mechanisms affecting dilations of human coronary arterioles. METHODS AND RESULTS: Agonist-induced dilations were assessed in isolated pressurized coronary arterioles from patients (n=38) who underwent cardiac surgery. Among normotensives we found that dilations to bradykinin (BK) and the NO-donor, sodium-nitroprusside (SNP) were reduced in obese subjects (BK, 10(-7) mol/L, lean: 90+/-4%, obese: 64+/-7%; SNP, 10(-6) mol/L, lean: 89+/-7%, obese: 76+/-5%). However, among hypertensives, both BK- and SNP-induced dilations were significantly enhanced in obese patients, when compared with lean individuals (BK, lean: 71+/-7%, obese: 85+/-3%; SNP, lean: 60+/-6%, obese: 83+/-2%). Correspondingly, in hypertensive patients, but not in those of normotensives, a positive correlation was found between body mass index (BMI) and BK-induced (P=0.036, r=0.46), and also SNP-evoked (P=0.031, r=0.44) coronary dilations. Moreover, in additional 55 hypertensive patients flow-mediated (FMD) and nitroglycerin (NTG)-induced dilations of the brachial artery were assessed. In obese hypertensive individuals, FMD- and NTG-induced dilations were greater (FMD: 6.2+/-0.7%, NTG: 17.2+/-0.9%), than in lean hypertensive patients (FMD: 3.7+/-0.6%, NTG: 13.6+/-1.1%). Correspondingly, FMD- and NTG-induced dilations were positively correlated with BMI (P=0.020, r=0.31 and P=0.033, r=0.29, respectively). CONCLUSIONS: These findings are the first to suggest that obesity may lead to activation of adaptive vascular mechanisms to enhance the dilator function of coronary and peripheral arterial vessels in hypertensive patients.
Authors:
Tibor Fulop; Eva Jebelovszki; Nora Erdei; Tamas Szerafin; Tamas Forster; Istvan Edes; Akos Koller; Zsolt Bagi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-09-06
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  27     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-18     Completed Date:  2007-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2348-54     Citation Subset:  IM    
Affiliation:
Institute of Cardiology, University of Debrecen, Moricz Zs. Krt. 22, 4032-Debrecen, Hungary.
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MeSH Terms
Descriptor/Qualifier:
Aged
Arterioles / physiopathology
Body Mass Index
Brachial Artery / physiopathology*,  ultrasonography
Bradykinin / pharmacology,  physiology
Coronary Vessels / physiopathology*
Female
Humans
Hypertension / complications,  physiopathology*
Male
Middle Aged
Nitroglycerin / pharmacology
Nitroprusside / pharmacology
Obesity / complications,  physiopathology*
Vasodilation / drug effects,  physiology*
Vasodilator Agents / pharmacology
Chemical
Reg. No./Substance:
0/Vasodilator Agents; 15078-28-1/Nitroprusside; 55-63-0/Nitroglycerin; 58-82-2/Bradykinin

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