Document Detail

Adaptation of vasomotor function of human coronary arterioles to the simultaneous presence of obesity and hypertension.
MedLine Citation:
PMID:  17823369     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We hypothesized that simultaneous presence of obesity and hypertension activates adaptive vascular mechanisms affecting dilations of human coronary arterioles. METHODS AND RESULTS: Agonist-induced dilations were assessed in isolated pressurized coronary arterioles from patients (n=38) who underwent cardiac surgery. Among normotensives we found that dilations to bradykinin (BK) and the NO-donor, sodium-nitroprusside (SNP) were reduced in obese subjects (BK, 10(-7) mol/L, lean: 90+/-4%, obese: 64+/-7%; SNP, 10(-6) mol/L, lean: 89+/-7%, obese: 76+/-5%). However, among hypertensives, both BK- and SNP-induced dilations were significantly enhanced in obese patients, when compared with lean individuals (BK, lean: 71+/-7%, obese: 85+/-3%; SNP, lean: 60+/-6%, obese: 83+/-2%). Correspondingly, in hypertensive patients, but not in those of normotensives, a positive correlation was found between body mass index (BMI) and BK-induced (P=0.036, r=0.46), and also SNP-evoked (P=0.031, r=0.44) coronary dilations. Moreover, in additional 55 hypertensive patients flow-mediated (FMD) and nitroglycerin (NTG)-induced dilations of the brachial artery were assessed. In obese hypertensive individuals, FMD- and NTG-induced dilations were greater (FMD: 6.2+/-0.7%, NTG: 17.2+/-0.9%), than in lean hypertensive patients (FMD: 3.7+/-0.6%, NTG: 13.6+/-1.1%). Correspondingly, FMD- and NTG-induced dilations were positively correlated with BMI (P=0.020, r=0.31 and P=0.033, r=0.29, respectively). CONCLUSIONS: These findings are the first to suggest that obesity may lead to activation of adaptive vascular mechanisms to enhance the dilator function of coronary and peripheral arterial vessels in hypertensive patients.
Tibor Fulop; Eva Jebelovszki; Nora Erdei; Tamas Szerafin; Tamas Forster; Istvan Edes; Akos Koller; Zsolt Bagi
Related Documents :
8490289 - Effect of cold stress on coronary sinus blood flow in patients with scleroderma.
22436709 - Investigating perioperative heart migration during robot-assisted coronary artery bypas...
1251909 - Intramyocardial distribution of blood flow in hemorrhagic shock in anesthetized dogs.
8137499 - Inhibition of nitric oxide production aggravates myocardial hypoperfusion during exerci...
21343239 - Right ventricular pacing impairs endothelial function in man.
9355909 - Inotropic effects of glyceryl trinitrate and spontaneous no donors in the dog heart.
7791689 - Time-frequency spectral analysis of electric field plethysmography signals.
1813859 - 99-m technetium (dupont cardiolite) investigations in postinfarction patients with holt...
19101229 - Relation of plaque characteristics defined by coronary computed tomographic angiography...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-09-06
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  27     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-18     Completed Date:  2007-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2348-54     Citation Subset:  IM    
Institute of Cardiology, University of Debrecen, Moricz Zs. Krt. 22, 4032-Debrecen, Hungary.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arterioles / physiopathology
Body Mass Index
Brachial Artery / physiopathology*,  ultrasonography
Bradykinin / pharmacology,  physiology
Coronary Vessels / physiopathology*
Hypertension / complications,  physiopathology*
Middle Aged
Nitroglycerin / pharmacology
Nitroprusside / pharmacology
Obesity / complications,  physiopathology*
Vasodilation / drug effects,  physiology*
Vasodilator Agents / pharmacology
Reg. No./Substance:
0/Vasodilator Agents; 15078-28-1/Nitroprusside; 55-63-0/Nitroglycerin; 58-82-2/Bradykinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Angiotensin II stimulates protein kinase D-dependent histone deacetylase 5 phosphorylation and nucle...
Next Document:  Pitx2c and Nkx2-5 are required for the formation and identity of the pulmonary myocardium.